A case of liver metastasis from gastric cancer responding completely to S-1/docetaxel chemotherapy

Hirokazu Kitahara, Eiji Oki, Hiroki Saeki, Koji Ando, Ken Shirabe, Shunji Kounoe, Shinichi Aishima, Yoshihiro Kakeji, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

Abstract

A 68-year-old man was introduced to our hospital with right lower abdominal pain. Endoscopic examination and abdominal CT revealed gastric cancer with liver metastasis. We started chemotherapy using S-1 (120 mg/body/day), orally administered for 2 weeks followed by a 2-week rest period, and docetaxel (35 mg/m2), administered intravenously on day 1 and 15 as 1 course. After 4 courses of chemotherapy, the liver tumor reduced markedly and no new cancerous region was found by examination; therefore total gastrectomy and partial hepatectomy were performed. Histological examination showed an undifferentiated adenocarcinoma remaining as Grade 1b in the resected stomach. A resected specimen of the liver showed necrotic tissue without any cancer cells. This case suggests that S-1/docetaxel chemotherapy may reduce the stage of unresectable liver metastasis from gastric cancer and make a curative operation possible.

Original languageEnglish
Pages (from-to)1093-1097
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume40
Issue number8
Publication statusPublished - Aug 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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