A case of locally, advanced pancreatic cancer with superior membrane artery invasion successfully resected after gemcitabine-based chemoradiotherapy

Yoshiaki Ohmura, Yutaka Takeda, Hiroaki Nagano, Shoji Nakamori, Shogo Kobayashi, Shigeru Marubashi, Hidetoshi Eguchi, Masahiro Tanemura, Toru Kitagawa, Morito Monden, Masaki Mori, Yuichiro Doki

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Abstract

A 69-year-old man with chief complaint of epigastralgia was diagnosed as locally advanced borderline unresectable pancreatic head cancer that involved superior membrane artery (SMA); Gemcitabine (GEM) -based chemoradiotherapy (CRT) was administered for consecutive 3 weeks in the following fashion: continuous twice-a-day accelerated radiotherapy (2 daily fractions of 1.5 Gy, 5 days a week, with a 6-hr minimal interval between fractions) with 3-time weekly intravenous infusions of GEM. Total radiation dose was 45 Gy and GEM was given on days 1, 8 and 15 at dose of 800mg/m2. After the completion of CRT, the involvement of SMA remained. Next, additional systemic chemotherapy with GEM was performed for 3 weeks in the following fashion: weekly intravenous infusions of GEM at dose of 1, 000 mg/m2. Finally, the main tumor and the invasion to SMA were reduced. Surgical resection with negative margins (R0 resection) was performed. Adjuvant chemotherapy with 6 courses of GEM was also performed. The patient has no recurrence, suggesting the efficacy of GEM-based, CRT for locally advanced borderline unresectable pancreatic cancer.

Original languageEnglish
Pages (from-to)2428-2429
Number of pages2
JournalJapanese Journal of Cancer and Chemotherapy
Volume36
Issue number12
Publication statusPublished - 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Ohmura, Y., Takeda, Y., Nagano, H., Nakamori, S., Kobayashi, S., Marubashi, S., Eguchi, H., Tanemura, M., Kitagawa, T., Monden, M., Mori, M., & Doki, Y. (2009). A case of locally, advanced pancreatic cancer with superior membrane artery invasion successfully resected after gemcitabine-based chemoradiotherapy. Japanese Journal of Cancer and Chemotherapy, 36(12), 2428-2429.