TY - JOUR
T1 - A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis
AU - Ohta, Miho
AU - Moriyama, Masafumi
AU - Goto, Yuichi
AU - Kawano, Shintaro
AU - Tanaka, Akihiko
AU - Maehara, Takashi
AU - Furukawa, Sachiko
AU - Hayashida, Jun Nosuke
AU - Kiyoshima, Tamotsu
AU - Shimizu, Mayumi
AU - Arinobu, Yojiro
AU - Nakamura, Seiji
N1 - Funding Information:
Acknowledgements This work was supported in part by grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (26293430, 26670869), the 'Research on Measures for Intractable Diseases' project, a matching fund subsidy from the Ministry of Health Labour and Welfare, Japan (H26-026, H26-050, H26-064, H26-083) and the 'Takeda Science Foundation'.
Funding Information:
This work was supported in part by grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (26293430, 26670869), the ‘Research on Measures for Intractable Diseases’ project, a matching fund subsidy from the Ministry of Health Labour and Welfare, Japan (H26-026, H26-050, H26-064, H26-083) and the ‘Takeda Science Foundation’.
Publisher Copyright:
© 2015 Ohta et al.
PY - 2015/2/21
Y1 - 2015/2/21
N2 - Background: IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease). Case presentation: We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma. Conclusion: Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.
AB - Background: IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease). Case presentation: We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma. Conclusion: Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.
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U2 - 10.1186/s12957-015-0459-z
DO - 10.1186/s12957-015-0459-z
M3 - Article
C2 - 25889621
AN - SCOPUS:84928735379
VL - 13
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
SN - 1477-7819
IS - 1
M1 - 67
ER -
