Abstract
Background: IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease). Case presentation: We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma. Conclusion: Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.
| Original language | English |
|---|---|
| Article number | 67 |
| Journal | World Journal of Surgical Oncology |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 21 2015 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oncology
Cite this
A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis. / Ohta, Miho; Moriyama, Masafumi; Goto, Yuichi; Kawano, Shintaro; Tanaka, Akihiko; Maehara, Takashi; Furukawa, Sachiko; Hayashida, Jun Nosuke; Kiyoshima, Tamotsu; Shimizu, Mayumi; Arinobu, Yojiro; Nakamura, Seiji.
In: World Journal of Surgical Oncology, Vol. 13, No. 1, 67, 21.02.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis
AU - Ohta, Miho
AU - Moriyama, Masafumi
AU - Goto, Yuichi
AU - Kawano, Shintaro
AU - Tanaka, Akihiko
AU - Maehara, Takashi
AU - Furukawa, Sachiko
AU - Hayashida, Jun Nosuke
AU - Kiyoshima, Tamotsu
AU - Shimizu, Mayumi
AU - Arinobu, Yojiro
AU - Nakamura, Seiji
PY - 2015/2/21
Y1 - 2015/2/21
N2 - Background: IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease). Case presentation: We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma. Conclusion: Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.
AB - Background: IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease). Case presentation: We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma. Conclusion: Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.
UR - http://www.scopus.com/inward/record.url?scp=84928735379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928735379&partnerID=8YFLogxK
U2 - 10.1186/s12957-015-0459-z
DO - 10.1186/s12957-015-0459-z
M3 - Article
C2 - 25889621
AN - SCOPUS:84928735379
VL - 13
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
SN - 1477-7819
IS - 1
M1 - 67
ER -