A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis

Miho Ohta, Masafumi Moriyama, Yuichi Goto, Shintaro Kawano, Akihiko Tanaka, Takashi Maehara, Sachiko Furukawa, Jun Nosuke Hayashida, Tamotsu Kiyoshima, Mayumi Shimizu, Yojiro Arinobu, Seiji Nakamura

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Abstract

Background: IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease). Case presentation: We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma. Conclusion: Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.

Original languageEnglish
Article number67
JournalWorld Journal of Surgical Oncology
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 21 2015

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Dacryocystitis
Sialadenitis
Marginal Zone B-Cell Lymphoma
Immunoglobulin G
Lymphoma
Submandibular Gland
Mikulicz' Disease
Giant Lymph Node Hyperplasia
Biopsy
Granulomatosis with Polyangiitis
Parotid Gland
Sarcoidosis
Plasma Cells
Serum
Differential Diagnosis
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis. / Ohta, Miho; Moriyama, Masafumi; Goto, Yuichi; Kawano, Shintaro; Tanaka, Akihiko; Maehara, Takashi; Furukawa, Sachiko; Hayashida, Jun Nosuke; Kiyoshima, Tamotsu; Shimizu, Mayumi; Arinobu, Yojiro; Nakamura, Seiji.

In: World Journal of Surgical Oncology, Vol. 13, No. 1, 67, 21.02.2015.

Research output: Contribution to journalArticle

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AU - Tanaka, Akihiko

AU - Maehara, Takashi

AU - Furukawa, Sachiko

AU - Hayashida, Jun Nosuke

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