A case of a mixed tumor of the skin on the upper lip of a 40-year-old man who had had it for 15 years is reported. It had developed to 15 mm in diameter and contained hypopigmented spots. We initially thought it was a follicular adnexal tumor and resected it The histological examination revealed a thickened epidermis with hyperkeratosis and papillomatous changes. In addition, large and small nests became apparent with the decapitation in some glands and stroma with myxomatous and fibromatous changes. Immunohistochemical staining provided a diagnosis of the mixed tumor of the skin, apocrine type. We discuss ten cases that were diagnosed as mixed tumors of the skin at the Department of Dermatology of Kyushu Medical Center and Kyushu University. The papillomatous change in the epidermis of a mixed tumor could be a rare case.
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