A case of multiple system atrophy-parkinsonian type with stuttering- and palilalia-like dysfluencies and putaminal atrophy

Yoshikazu Kikuchi, Toshiro Umezaki, Taira Uehara, Hiroo Yamaguchi, Koji Yamashita, Akio Hiwatashi, Motohiro Sawatsubashi, Kazuo Adachi, Yumi Yamaguchi, Daisuke Murakami, Jun ichi Kira, Takashi Nakagawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Both developmental and acquired stuttering are related to the function of the basal ganglia-thalamocortical loop, which includes the putamen. Here, we present a case of stuttering- and palilalia-like dysfluencies that manifested as an early symptom of multiple system atrophy-parkinsonian type (MSA-P) and bilateral atrophy of the putamen. The patient was a 72-year-old man with no history of developmental stuttering who presented with a stutter for consultation with our otorhinolaryngology department. The patient was diagnosed with MSA-P based on parkinsonism, autonomic dysfunction, and bilateral putaminal atrophy revealed by T2-weighted magnetic resonance imaging. Treatment with levodopa improved both the motor functional deficits related to MSA-P and stuttering-like dysfluencies while reading; however, the palilalia-like dysfluencies were much less responsive to levodopa therapy. The patient died of aspiration pneumonia two years after his first consultation at our hospital. In conclusion, adult-onset stuttering- and palilalia-like dysfluencies warrant careful examination of the basal ganglia-thalamocortical loop, and especially the putamen, using neuroimaging techniques. Acquired stuttering may be related to deficits in dopaminergic function.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalJournal of Fluency Disorders
Volume57
DOIs
Publication statusPublished - Sep 2018

Fingerprint

Multiple System Atrophy
Stuttering
Atrophy
deficit
Putamen
Levodopa
Basal Ganglia
Referral and Consultation
examination
Aspiration Pneumonia
Otolaryngology
Parkinsonian Disorders
Dysfluency
Neuroimaging
Reading
Magnetic Resonance Imaging
Therapeutics
Developmental Stuttering
Acquired Stuttering

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing
  • LPN and LVN

Cite this

A case of multiple system atrophy-parkinsonian type with stuttering- and palilalia-like dysfluencies and putaminal atrophy. / Kikuchi, Yoshikazu; Umezaki, Toshiro; Uehara, Taira; Yamaguchi, Hiroo; Yamashita, Koji; Hiwatashi, Akio; Sawatsubashi, Motohiro; Adachi, Kazuo; Yamaguchi, Yumi; Murakami, Daisuke; Kira, Jun ichi; Nakagawa, Takashi.

In: Journal of Fluency Disorders, Vol. 57, 09.2018, p. 51-58.

Research output: Contribution to journalArticle

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