A case of neurofascin-155 antibody-positive chronic inflammatory demyelinating polyradiculoneuropathy successfully treated with Cyclosporine A

Daisuke Sato, Hidenori Ogata, Motoi Kuwahara, Junichi Kira, Susumu Kusunoki, Yoshihiro Suzuki

Research output: Contribution to journalArticle

Abstract

A 41-year-old man noticed numbness of the fingers and toes, and gradually developed limb weakness and sensory impairment. The patient was diagnosed with typical chronic inflammatory demyelinating polyradiculoneuropathy. Over the course of clinical diagnosis, the limb and trunk ataxia, and finger tremor became prominent, and the presence anti-neurofascin-155 antibody was examined and confirmed positive. The effects of corticosteroids, intravenous immunoglobulin, and plasma apheresis were limited, and the disease progressed slowly and noticeably. Therefore, cyclosporine was introduced as treatment, and the patient's weakness and ataxia significantly improved. Rituximab treatment is expected to be effective in patients with the same antibody and immunosuppressant treatment may be useful in intractable cases.

Original languageEnglish
Pages (from-to)533-537
Number of pages5
JournalClinical Neurology
Volume60
Issue number8
DOIs
Publication statusPublished - Aug 7 2020

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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