A case of non-convulsive status epilepticus after influenza virus B infection

Hayato Une, Taira Uehara, Takahisa Tateishi, Hiroshi Shigetou, Yasumasa Oyagi, Jun Ichi Kira

Research output: Contribution to journalArticle

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Abstract

A 24-year-old woman was referred to our hospital because of impaired consciousness after influenza virus B infection. Neurological examination revealed mild disturbance of consciousness without other neurological abnormalities. Laboratory tests showed elevated serum CRP, IL-6 and TNF-α levels. The level of IL-6 in the cerebrospinal fluid was also slightly elevated. Electroencephalography (EEG) disclosed almost continuous generalized spike and wave complexes and multiple spikes and wave complexes at 1.5-3 Hz. Brain MRI was normal. She was diagnosed as having influenza encephalopathy presenting non-convulsive status epilepticus (NCSE), and commenced methylprednisolone pulse therapy followed by prednisolone with gradual tapering. She was also treated with intravenous phenytoin and oral sodium valproate for NCSE. The next day, her consciousness level had improved. Although she became alert, epileptic discharges on EEG were still observed on the seventh hospital day, and levetiracetam was added. Then, her epileptic discharges almost completely disappeared on the twelfth hospital day. She was discharged without any neurological deficit. We consider this patient to be a case of transient NCSE due to influenza encephalopathy; alternatively, she may have epileptic traits and her NCSE may have been provoked by influenza virus infection.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalClinical Neurology
Volume54
Issue number3
DOIs
Publication statusPublished - Mar 2014

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Status Epilepticus
Virus Diseases
Orthomyxoviridae
Consciousness
etiracetam
Brain Diseases
Human Influenza
Electroencephalography
Interleukin-6
Methylprednisolone
Neurologic Examination
Valproic Acid
Phenytoin
Prednisolone
Cerebrospinal Fluid
Brain
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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A case of non-convulsive status epilepticus after influenza virus B infection. / Une, Hayato; Uehara, Taira; Tateishi, Takahisa; Shigetou, Hiroshi; Oyagi, Yasumasa; Kira, Jun Ichi.

In: Clinical Neurology, Vol. 54, No. 3, 03.2014, p. 227-230.

Research output: Contribution to journalArticle

Une, Hayato ; Uehara, Taira ; Tateishi, Takahisa ; Shigetou, Hiroshi ; Oyagi, Yasumasa ; Kira, Jun Ichi. / A case of non-convulsive status epilepticus after influenza virus B infection. In: Clinical Neurology. 2014 ; Vol. 54, No. 3. pp. 227-230.
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