A case of non-pigmented basal cell carcinoma on the dorsum of the nose

Hiromi Maemura, Nanae Kimura, Hiroko Takamatsu, Kayo Harada, Kazunori Urabe, Masutaka Furue

Research output: Contribution to journalArticle

Abstract

A 77-year-old woman visited us complaining of a nasal macule that had been gradually enlarging for 14 months. Previous topical corticosteroid application was ineffective. Physical examination revealed a hemorrhagic erythematous lesion with crust measuring 36 × 30 mm in diameter on the right side of her nose. On dermoscopy, telangiectasia and arborizing vessels were conspicuous without any pigmented spots or dots. Histopathologically, atypical basaloid cells were found to be proliferating in nests with peripheral palisading. However, melanin granules in the nests and peritumoral melanophages were not found, leading us to the diagnosis of non-pigmented basal cell carcinoma. Further immunohistological examination elucidated that Melan-A-positive melanocytes existed in the tumor nests; however, they were not stained by tyrosinase and Fontana-Masson staining. These results indicated that the inhibition of eumelanin biosynthesis in melanocytes would explain the hypopigmented nature of her basal cell carcinoma.

Original languageEnglish
Pages (from-to)371-375
Number of pages5
JournalNishinihon Journal of Dermatology
Volume79
Issue number4
DOIs
Publication statusPublished - Jan 1 2017

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Melanocytes
Basal Cell Carcinoma
Nose
MART-1 Antigen
Dermoscopy
Telangiectasis
Monophenol Monooxygenase
Melanins
Physical Examination
Adrenal Cortex Hormones
Staining and Labeling
Neoplasms
eumelanin

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

A case of non-pigmented basal cell carcinoma on the dorsum of the nose. / Maemura, Hiromi; Kimura, Nanae; Takamatsu, Hiroko; Harada, Kayo; Urabe, Kazunori; Furue, Masutaka.

In: Nishinihon Journal of Dermatology, Vol. 79, No. 4, 01.01.2017, p. 371-375.

Research output: Contribution to journalArticle

Maemura, Hiromi ; Kimura, Nanae ; Takamatsu, Hiroko ; Harada, Kayo ; Urabe, Kazunori ; Furue, Masutaka. / A case of non-pigmented basal cell carcinoma on the dorsum of the nose. In: Nishinihon Journal of Dermatology. 2017 ; Vol. 79, No. 4. pp. 371-375.
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