A case of paroxysmal sympathetic storm after acute disseminated encephalomyelitis and hypoxic encephalopathy responding to clonidine hydrochloride

Mitsunori Shimmura, Nobutoshi Kawamura, Takahisa Tateishi, Hiroshi Shigeto, Hiroyuki Murai, Jun Ichi Kira

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report the case of a 17-year-old woman with paroxysmal sympathetic storm (PSS), which was successfully treated with clonidine hydrochloride. The patient was hospitalized for acute disseminated encephalomyelitis in June 2006. Dysphagia led to severe aspiration pneumonia in September 2006, and she suffered cardiopulmonary arrest. She survived but had severe brain damage, with her brain MRI showing diffuse hypoxic encephalopathy. From October 2006, she had several episodes of profound tachypnea (< 60/min), tachycardia (160 to 170 beats/min), hypertension (< 140 mmHg), hyperthermia (39°C), and decerebrate posturing. During the attacks, the levels of catecholamines in the patient's blood and urine were markedly elevated. Accordingly, a diagnosis of PSS associated with hypoxic encephalopathy was made. Her PSS clearly improved after the administration of clonidine hydrochloride (900 μg/day). This case suggests that clonidine hydrochloride, an α2 blocker, may be one therapeutic option for PSS.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalClinical Neurology
Volume56
Issue number2
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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