Abstract
We report the case of a 17-year-old woman with paroxysmal sympathetic storm (PSS), which was successfully treated with clonidine hydrochloride. The patient was hospitalized for acute disseminated encephalomyelitis in June 2006. Dysphagia led to severe aspiration pneumonia in September 2006, and she suffered cardiopulmonary arrest. She survived but had severe brain damage, with her brain MRI showing diffuse hypoxic encephalopathy. From October 2006, she had several episodes of profound tachypnea (< 60/min), tachycardia (160 to 170 beats/min), hypertension (< 140 mmHg), hyperthermia (39°C), and decerebrate posturing. During the attacks, the levels of catecholamines in the patient's blood and urine were markedly elevated. Accordingly, a diagnosis of PSS associated with hypoxic encephalopathy was made. Her PSS clearly improved after the administration of clonidine hydrochloride (900 μg/day). This case suggests that clonidine hydrochloride, an α2 blocker, may be one therapeutic option for PSS.
| Original language | English |
|---|---|
| Pages (from-to) | 108-111 |
| Number of pages | 4 |
| Journal | Clinical Neurology |
| Volume | 56 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 2016 |
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All Science Journal Classification (ASJC) codes
- Clinical Neurology
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A case of paroxysmal sympathetic storm after acute disseminated encephalomyelitis and hypoxic encephalopathy responding to clonidine hydrochloride. / Shimmura, Mitsunori; Kawamura, Nobutoshi; Tateishi, Takahisa; Shigeto, Hiroshi; Murai, Hiroyuki; Kira, Jun Ichi.
In: Clinical Neurology, Vol. 56, No. 2, 01.01.2016, p. 108-111.Research output: Contribution to journal › Article
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TY - JOUR
T1 - A case of paroxysmal sympathetic storm after acute disseminated encephalomyelitis and hypoxic encephalopathy responding to clonidine hydrochloride
AU - Shimmura, Mitsunori
AU - Kawamura, Nobutoshi
AU - Tateishi, Takahisa
AU - Shigeto, Hiroshi
AU - Murai, Hiroyuki
AU - Kira, Jun Ichi
PY - 2016/1/1
Y1 - 2016/1/1
N2 - We report the case of a 17-year-old woman with paroxysmal sympathetic storm (PSS), which was successfully treated with clonidine hydrochloride. The patient was hospitalized for acute disseminated encephalomyelitis in June 2006. Dysphagia led to severe aspiration pneumonia in September 2006, and she suffered cardiopulmonary arrest. She survived but had severe brain damage, with her brain MRI showing diffuse hypoxic encephalopathy. From October 2006, she had several episodes of profound tachypnea (< 60/min), tachycardia (160 to 170 beats/min), hypertension (< 140 mmHg), hyperthermia (39°C), and decerebrate posturing. During the attacks, the levels of catecholamines in the patient's blood and urine were markedly elevated. Accordingly, a diagnosis of PSS associated with hypoxic encephalopathy was made. Her PSS clearly improved after the administration of clonidine hydrochloride (900 μg/day). This case suggests that clonidine hydrochloride, an α2 blocker, may be one therapeutic option for PSS.
AB - We report the case of a 17-year-old woman with paroxysmal sympathetic storm (PSS), which was successfully treated with clonidine hydrochloride. The patient was hospitalized for acute disseminated encephalomyelitis in June 2006. Dysphagia led to severe aspiration pneumonia in September 2006, and she suffered cardiopulmonary arrest. She survived but had severe brain damage, with her brain MRI showing diffuse hypoxic encephalopathy. From October 2006, she had several episodes of profound tachypnea (< 60/min), tachycardia (160 to 170 beats/min), hypertension (< 140 mmHg), hyperthermia (39°C), and decerebrate posturing. During the attacks, the levels of catecholamines in the patient's blood and urine were markedly elevated. Accordingly, a diagnosis of PSS associated with hypoxic encephalopathy was made. Her PSS clearly improved after the administration of clonidine hydrochloride (900 μg/day). This case suggests that clonidine hydrochloride, an α2 blocker, may be one therapeutic option for PSS.
UR - http://www.scopus.com/inward/record.url?scp=84961174178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961174178&partnerID=8YFLogxK
U2 - 10.5692/clinicalneurol.cn-000793
DO - 10.5692/clinicalneurol.cn-000793
M3 - Article
C2 - 26754594
AN - SCOPUS:84961174178
VL - 56
SP - 108
EP - 111
JO - Clinical Neurology
JF - Clinical Neurology
SN - 0009-918X
IS - 2
ER -