A case of PBC-AIH overlap syndrome with systemic sclerosis and liver scar

Nobuyuki Yamashita, Yugo Miyagi, Shinji Simoda, Fumiko Hori, Hironori Tanimoto, Yasunori Ichiki, Hidetaka Yamamoto, Hideyuki Nomura

Research output: Contribution to journalArticlepeer-review

Abstract

A sixties year-old man with a history of systemic sclerosis was referred to our hospital because of elevated liver enzymes. Abdominal finding of images showed massive hepatic necrosis near the diaphragm. Elevated ALP, AMA positive, and histological findings as PBC and elevated ALT and histological interface hepatitis findings as AIH indicated the diagnosis as overlap syndrome. Even though this case had good response with corticosteroid and UDCA therapy, hepatic scar and deformation remained after 6 months later. Liver biopsy must be considered aggressively in case of patients with collagen diseases who had elevated liver enzymes.

Original languageEnglish
Pages (from-to)487-495
Number of pages9
JournalActa Hepatologica Japonica
Volume57
Issue number9
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Hepatology

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