A case of peritonitis carcinomatosa from goblet cell carcinoid of the appendix treated by intraperitoneal paclitaxel and systemic S-1 chemotherapy

Shingen Nakamura, Shigeaki Kimura, Masahiro Kashima, Kana Shichijo, Sumiko Yoshida, Eiji Harada, Takaya Matsushita, Yasushi Oshima, Yasutami Tamaki, Noriaki Horiuchi, Toshiaki Takeichi, Hiroshi Fujimoto, Kazuhiko Masuda, Naohito Iwasaka, Sadao Shinomiya

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Abstract

Goblet cell carcinoid of the appendix is a rare neoplasm and clinically tends to take a malignant course. Most cases are young and early stage, and the surgical strategy is available. But appropriate chemotherapy for inoperable cases with peritoneal dissemination is not established. A 77-year-old woman with a past history of appendectomy was admitted to our hospital complaining of abdominal fullness. Abdominal computed tomography showed massive ascites and slight contrast enhancement of appendix. A tumor was found by colonoscopic examination at the orifice of vermiform and was diagnosed pathologically as goblet cell carcinoid of the appendix. Laparoscopy showed multiple peritoneal dissemination. We performed intraperitoneal paclitaxel(PTX)administration at 70 mg/m(2) week without any resection of the tumor. Ascites were reduced immediately, but drug-induced interstitial pneumonia occurred due to PTX. After steroid therapy, we switched to systemic S-1 therapy. For about one year, her tumor was controlled but became worse thirteen months after diagnosis and died. It is thought that intraabdominal paclitaxel administration and systemic S-1 therapy can be one of appropriate forms of chemotherapy for inoperable peritoneal carcinomatosis from goblet cell carcinoid of appendix.

Original languageEnglish
Pages (from-to)2425-2428
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume35
Issue number13
Publication statusPublished - Jan 1 2008
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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