A case of poisoning in a man who drank a nutrition supplement containing methomyl, a carbamate pesticide.

Keiko Kudo, Yoshihiro Hida, Akinori Zaitsu, Hiromasa Inoue, Akiko Tsuji, Tomomi Ishida, Noriaki Ikeda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 50-year-old man was admitted to the emergency room complaining oppression on his chest, sweating and vomiting. He had drunk a 30 ml volume nutrition supplement 60 minutes before. As myosis and decrease of serum choline esterase activity were observed on admission examination, poisoning was suspected and toxicological analyses were carried out on the heeltap of the drink. Drug screening by gas chromatography-mass spectrometry (GC/MS) revealed the presence of methomyl and the concentration of methomyl in the heeltap determined by liquid chromatography was 2.1 mg/ml. Methomyl concentrations in the serum and urine were determined after converting methomyl to its oxime form followed by derivatization and GC/MS. Methomyl concentration in the serum collected 6 hours after ingestion was 0.63 microg/ml, and that in the urine collected 7-20 hours after ingestion was 0.10 microg/ml. Based on these values and reported data, the amount of methomyl contaminated to the drink was considered to be a toxic dose.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume96
Issue number7
Publication statusPublished - Jul 2005

Fingerprint

Methomyl
Carbamates
Pesticides
Poisoning
Gas Chromatography-Mass Spectrometry
Eating
Serum
Urine
Miosis
Preclinical Drug Evaluations
Sweating
Oximes
Poisons
Esterases
Choline
Liquid Chromatography
Toxicology
Vomiting
Hospital Emergency Service
Thorax

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

A case of poisoning in a man who drank a nutrition supplement containing methomyl, a carbamate pesticide. / Kudo, Keiko; Hida, Yoshihiro; Zaitsu, Akinori; Inoue, Hiromasa; Tsuji, Akiko; Ishida, Tomomi; Ikeda, Noriaki.

In: Fukuoka igaku zasshi = Hukuoka acta medica, Vol. 96, No. 7, 07.2005, p. 305-310.

Research output: Contribution to journalArticle

Kudo, Keiko ; Hida, Yoshihiro ; Zaitsu, Akinori ; Inoue, Hiromasa ; Tsuji, Akiko ; Ishida, Tomomi ; Ikeda, Noriaki. / A case of poisoning in a man who drank a nutrition supplement containing methomyl, a carbamate pesticide. In: Fukuoka igaku zasshi = Hukuoka acta medica. 2005 ; Vol. 96, No. 7. pp. 305-310.
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AU - Ishida, Tomomi

AU - Ikeda, Noriaki

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