TY - JOUR
T1 - A case of primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma
AU - Sasaki, Yoshiko
AU - Uchi, Hiroshi
AU - Moroi, Yoichi
AU - Furue, Masutaka
PY - 2015
Y1 - 2015
N2 - A 72-year-old female patient was referred to us for a 2-month history of an asymptomatic erythematous nodule on her left chest, which had been suspected to be a malignant lymphoma due to the results of an aspiration biopsy. Physical examination revealed a well-circumscribed and dome-shaped nodule measuring 2 cm in diameter on her left chest. Histopathologic features included a diffuse dermal infiltrate with extension into the subcutis, composed predominantly of small to medium-sized atypical lymphocytes. Epidermotropism was rarely seen. Immunohistochemically, atypical lymphocytes were CD3 positive, CD4 positive, and CD30 negative, and were associated with reactive CD8 positive T cells and CD20 positive B cells. The TCR gene was clonally rearranged. Soluble interleukin (IL)-2 receptor was within the normal range, and human T- lymphotrophic virus (HTLV) -1 antibody was negative. We diagnosed the patient as having primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma. The lesion was completely excised and no relapse had occurred at 33 months follow-up.
AB - A 72-year-old female patient was referred to us for a 2-month history of an asymptomatic erythematous nodule on her left chest, which had been suspected to be a malignant lymphoma due to the results of an aspiration biopsy. Physical examination revealed a well-circumscribed and dome-shaped nodule measuring 2 cm in diameter on her left chest. Histopathologic features included a diffuse dermal infiltrate with extension into the subcutis, composed predominantly of small to medium-sized atypical lymphocytes. Epidermotropism was rarely seen. Immunohistochemically, atypical lymphocytes were CD3 positive, CD4 positive, and CD30 negative, and were associated with reactive CD8 positive T cells and CD20 positive B cells. The TCR gene was clonally rearranged. Soluble interleukin (IL)-2 receptor was within the normal range, and human T- lymphotrophic virus (HTLV) -1 antibody was negative. We diagnosed the patient as having primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma. The lesion was completely excised and no relapse had occurred at 33 months follow-up.
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U2 - 10.2336/nishinihonhifu.77.43
DO - 10.2336/nishinihonhifu.77.43
M3 - Article
AN - SCOPUS:84937127331
SN - 0386-9784
VL - 77
SP - 43
EP - 46
JO - Nishinihon Journal of Dermatology
JF - Nishinihon Journal of Dermatology
IS - 1
ER -