A case of primary intraocular lymphoma resistant to methotrexate therapy

Miwa Kanaumi; Hiroshi Yoshikawa; Kohei Sonoda; Keijiro Ishikawa; Tatsuro Ishibashi

A case of primary intraocular lymphoma resistant to methotrexate therapy

Miwa Kanaumi, Hiroshi Yoshikawa, Kohei Sonoda, Keijiro Ishikawa, Tatsuro Ishibashi

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Treatment by methotrexate (MTX) for primary intraocular lymphoma (PIOL) has attracted attention in recent years. Case-report: A 51-year-old woman visited our hospital with binocular vitreous opacity that was unresponsive to therapy with corticosteroids. We diagnosed PIOL by the cytological findings and intraocular IL-10 level. Although her vitreous opacity disappeared by intravitreal MTX injection initially, in the course of repeated injections, MTX gradually became ineffective and subretinal tumor appeared, which did not respond to subsequent high-dose MTX therapy. Finally, by radiation therapy, the tumor cleared and her visual function improved. Conclusion: MTX therapy including high-dose MTX treatment may not be effective against PIOL.

Original language	English
Pages (from-to)	411-415
Number of pages	5
Journal	Folia Japonica de Ophthalmologica Clinica
Volume	2
Issue number	5
Publication status	Published - May 1 2009

All Science Journal Classification (ASJC) codes

Ophthalmology

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title = "A case of primary intraocular lymphoma resistant to methotrexate therapy",

abstract = "Background: Treatment by methotrexate (MTX) for primary intraocular lymphoma (PIOL) has attracted attention in recent years. Case-report: A 51-year-old woman visited our hospital with binocular vitreous opacity that was unresponsive to therapy with corticosteroids. We diagnosed PIOL by the cytological findings and intraocular IL-10 level. Although her vitreous opacity disappeared by intravitreal MTX injection initially, in the course of repeated injections, MTX gradually became ineffective and subretinal tumor appeared, which did not respond to subsequent high-dose MTX therapy. Finally, by radiation therapy, the tumor cleared and her visual function improved. Conclusion: MTX therapy including high-dose MTX treatment may not be effective against PIOL.",

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T1 - A case of primary intraocular lymphoma resistant to methotrexate therapy

AU - Kanaumi, Miwa

AU - Yoshikawa, Hiroshi

AU - Sonoda, Kohei

AU - Ishikawa, Keijiro

AU - Ishibashi, Tatsuro

PY - 2009/5/1

Y1 - 2009/5/1

N2 - Background: Treatment by methotrexate (MTX) for primary intraocular lymphoma (PIOL) has attracted attention in recent years. Case-report: A 51-year-old woman visited our hospital with binocular vitreous opacity that was unresponsive to therapy with corticosteroids. We diagnosed PIOL by the cytological findings and intraocular IL-10 level. Although her vitreous opacity disappeared by intravitreal MTX injection initially, in the course of repeated injections, MTX gradually became ineffective and subretinal tumor appeared, which did not respond to subsequent high-dose MTX therapy. Finally, by radiation therapy, the tumor cleared and her visual function improved. Conclusion: MTX therapy including high-dose MTX treatment may not be effective against PIOL.

AB - Background: Treatment by methotrexate (MTX) for primary intraocular lymphoma (PIOL) has attracted attention in recent years. Case-report: A 51-year-old woman visited our hospital with binocular vitreous opacity that was unresponsive to therapy with corticosteroids. We diagnosed PIOL by the cytological findings and intraocular IL-10 level. Although her vitreous opacity disappeared by intravitreal MTX injection initially, in the course of repeated injections, MTX gradually became ineffective and subretinal tumor appeared, which did not respond to subsequent high-dose MTX therapy. Finally, by radiation therapy, the tumor cleared and her visual function improved. Conclusion: MTX therapy including high-dose MTX treatment may not be effective against PIOL.

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A case of primary intraocular lymphoma resistant to methotrexate therapy

Abstract

All Science Journal Classification (ASJC) codes

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