A case of protein-losing gastroenteropathy accompanied by Sjögren syndrome and mixed connective tissue disease

Kana Kakigao; Nobuyoshi Fukushima; Takahiro Mizutani; Kazuhiro Haraguchi; Risa Okamoto; Noriko Sawamura; Tomoko Oohashi; Aya Mitsuyasu; Takashi Fujiyama; Tsuyoshi Yoshimoto; Motoyuki Koujima; Ken Kawabe; Kunitaka Fukuizumi; Makoto Nakamuta; Naohiko Harada

A case of protein-losing gastroenteropathy accompanied by Sjögren syndrome and mixed connective tissue disease

Kana Kakigao, Nobuyoshi Fukushima, Takahiro Mizutani, Kazuhiro Haraguchi, Risa Okamoto, Noriko Sawamura, Tomoko Oohashi, Aya Mitsuyasu, Takashi Fujiyama, Tsuyoshi Yoshimoto, Motoyuki Koujima, Ken Kawabe, Kunitaka Fukuizumi, Makoto Nakamuta, Naohiko Harada

Department of Hepatology and Pancreatology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Case reports of protein-losing gastroenteropathy (PLGE) associated with not only mixed connective tissue disease (MCTD) but also Sjögren syndrome (SjS) are very rare. We report a first case of PLGE in a patient with both MCTD and SjS. A 58-year-old Japanese woman was referred and admitted to our hospital because of abdominal fullness and lower leg edema Her past medical history revealed SjS at age 40. Physical examination demonstrated lower leg edema and Raynaud's phenomenon. Blood chemistry data showed severe hypoproteinemia. Anti RNP antibody was positive. MCTD was diagnosed. The alpha-1 antitrypsin clearance level was high. The ^99mTc-DTPA human serum albumin scintigraphy demonstrated abnormal accumulation in the intestine. PLGE associated with both MCTD and SjS was diagnosed, but she was successfully treated by prednisolone.

Original language	English
Pages (from-to)	1770-1775
Number of pages	6
Journal	Journal of Japanese Society of Gastroenterology
Volume	109
Issue number	10
Publication status	Published - Oct 2012

All Science Journal Classification (ASJC) codes

Gastroenterology

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Kakigao, K., Fukushima, N., Mizutani, T., Haraguchi, K., Okamoto, R., Sawamura, N., Oohashi, T., Mitsuyasu, A., Fujiyama, T., Yoshimoto, T., Koujima, M., Kawabe, K., Fukuizumi, K., Nakamuta, M., & Harada, N. (2012). A case of protein-losing gastroenteropathy accompanied by Sjögren syndrome and mixed connective tissue disease. Journal of Japanese Society of Gastroenterology, 109(10), 1770-1775.

A case of protein-losing gastroenteropathy accompanied by Sjögren syndrome and mixed connective tissue disease. / Kakigao, Kana; Fukushima, Nobuyoshi; Mizutani, Takahiro; Haraguchi, Kazuhiro; Okamoto, Risa; Sawamura, Noriko; Oohashi, Tomoko; Mitsuyasu, Aya; Fujiyama, Takashi; Yoshimoto, Tsuyoshi; Koujima, Motoyuki; Kawabe, Ken; Fukuizumi, Kunitaka; Nakamuta, Makoto; Harada, Naohiko.

In: Journal of Japanese Society of Gastroenterology, Vol. 109, No. 10, 10.2012, p. 1770-1775.

Research output: Contribution to journal › Article › peer-review

Kakigao, K, Fukushima, N, Mizutani, T, Haraguchi, K, Okamoto, R, Sawamura, N, Oohashi, T, Mitsuyasu, A, Fujiyama, T, Yoshimoto, T, Koujima, M, Kawabe, K, Fukuizumi, K, Nakamuta, M & Harada, N 2012, 'A case of protein-losing gastroenteropathy accompanied by Sjögren syndrome and mixed connective tissue disease', Journal of Japanese Society of Gastroenterology, vol. 109, no. 10, pp. 1770-1775.

Kakigao, Kana ; Fukushima, Nobuyoshi ; Mizutani, Takahiro ; Haraguchi, Kazuhiro ; Okamoto, Risa ; Sawamura, Noriko ; Oohashi, Tomoko ; Mitsuyasu, Aya ; Fujiyama, Takashi ; Yoshimoto, Tsuyoshi ; Koujima, Motoyuki ; Kawabe, Ken ; Fukuizumi, Kunitaka ; Nakamuta, Makoto ; Harada, Naohiko. / A case of protein-losing gastroenteropathy accompanied by Sjögren syndrome and mixed connective tissue disease. In: Journal of Japanese Society of Gastroenterology. 2012 ; Vol. 109, No. 10. pp. 1770-1775.

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abstract = "Case reports of protein-losing gastroenteropathy (PLGE) associated with not only mixed connective tissue disease (MCTD) but also Sj{\"o}gren syndrome (SjS) are very rare. We report a first case of PLGE in a patient with both MCTD and SjS. A 58-year-old Japanese woman was referred and admitted to our hospital because of abdominal fullness and lower leg edema Her past medical history revealed SjS at age 40. Physical examination demonstrated lower leg edema and Raynaud's phenomenon. Blood chemistry data showed severe hypoproteinemia. Anti RNP antibody was positive. MCTD was diagnosed. The alpha-1 antitrypsin clearance level was high. The 99mTc-DTPA human serum albumin scintigraphy demonstrated abnormal accumulation in the intestine. PLGE associated with both MCTD and SjS was diagnosed, but she was successfully treated by prednisolone.",

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AU - Sawamura, Noriko

AU - Oohashi, Tomoko

AU - Mitsuyasu, Aya

AU - Fujiyama, Takashi

AU - Yoshimoto, Tsuyoshi

AU - Koujima, Motoyuki

AU - Kawabe, Ken

AU - Fukuizumi, Kunitaka

AU - Nakamuta, Makoto

AU - Harada, Naohiko

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AB - Case reports of protein-losing gastroenteropathy (PLGE) associated with not only mixed connective tissue disease (MCTD) but also Sjögren syndrome (SjS) are very rare. We report a first case of PLGE in a patient with both MCTD and SjS. A 58-year-old Japanese woman was referred and admitted to our hospital because of abdominal fullness and lower leg edema Her past medical history revealed SjS at age 40. Physical examination demonstrated lower leg edema and Raynaud's phenomenon. Blood chemistry data showed severe hypoproteinemia. Anti RNP antibody was positive. MCTD was diagnosed. The alpha-1 antitrypsin clearance level was high. The 99mTc-DTPA human serum albumin scintigraphy demonstrated abnormal accumulation in the intestine. PLGE associated with both MCTD and SjS was diagnosed, but she was successfully treated by prednisolone.

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