A case of protein-losing gastroenteropathy accompanied by Sjögren syndrome and mixed connective tissue disease

Kana Kakigao, Nobuyoshi Fukushima, Takahiro Mizutani, Kazuhiro Haraguchi, Risa Okamoto, Noriko Sawamura, Tomoko Oohashi, Aya Mitsuyasu, Takashi Fujiyama, Tsuyoshi Yoshimoto, Motoyuki Koujima, Ken Kawabe, Kunitaka Fukuizumi, Makoto Nakamuta, Naohiko Harada

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Abstract

Case reports of protein-losing gastroenteropathy (PLGE) associated with not only mixed connective tissue disease (MCTD) but also Sjögren syndrome (SjS) are very rare. We report a first case of PLGE in a patient with both MCTD and SjS. A 58-year-old Japanese woman was referred and admitted to our hospital because of abdominal fullness and lower leg edema Her past medical history revealed SjS at age 40. Physical examination demonstrated lower leg edema and Raynaud's phenomenon. Blood chemistry data showed severe hypoproteinemia. Anti RNP antibody was positive. MCTD was diagnosed. The alpha-1 antitrypsin clearance level was high. The 99mTc-DTPA human serum albumin scintigraphy demonstrated abnormal accumulation in the intestine. PLGE associated with both MCTD and SjS was diagnosed, but she was successfully treated by prednisolone.

Original languageEnglish
Pages (from-to)1770-1775
Number of pages6
JournalJournal of Japanese Society of Gastroenterology
Volume109
Issue number10
Publication statusPublished - Oct 1 2012

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All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Kakigao, K., Fukushima, N., Mizutani, T., Haraguchi, K., Okamoto, R., Sawamura, N., ... Harada, N. (2012). A case of protein-losing gastroenteropathy accompanied by Sjögren syndrome and mixed connective tissue disease. Journal of Japanese Society of Gastroenterology, 109(10), 1770-1775.