A case of radiation fibrosis appearing as mass-like consolidation after SBRT with elevation of serum CEA

Kotaro Terashima, Yoshiyuki Shioyama, Satoshi Nomoto, Ohga Saiji, Takeshi Nonoshita, Kayoko Ohnishi, Kazushige Atsumi, Hidetake Yabuuchi, Hideki Hirata, Hiroshi Honda

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Abstract

We report a case of radiation fibrosis appearing as mass-like consolidation, which was difficult to distinguish fromlocal recurrence. A 72-year-old woman was diagnosed as having primary lung cancer (cT1N0M0 stage IA) in the right upper lobe and was treated with SBRT of 48 Gy in 4 fractions. After 12 months, mass-like consolidation appeared around the irradiated area, and after 13 months, it had increased in size. FDG-PET revealed high uptake (SUV max = 5.61) for the consolidation. CT-guided biopsy was performed, but we could not confirm the diagnosis. Considering her poor respiratory function and her age, short-interval follow-up was performed. After 15 months, the consolidation enlarged at the dorsal side, and carcinoembryonic antigen (CEA) became elevated (14.6 ng/mL). Serum KL-6 (436 U/mL) and SP-D (204 ng/mL) were also elevated. However, after 16 months, serum CEA slightly decreased. The consolidation gradually retracted on follow-up CT images. CEA, KL-6, and SP-D were also decreased by degrees. After 40 months, there is no evidence of local recurrence.

Original languageEnglish
Article number986706
JournalCase Reports in Medicine
Volume2010
DOIs
Publication statusPublished - Jan 1 2010

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Radiation Pneumonitis
Carcinoembryonic Antigen
Pulmonary Surfactant-Associated Protein D
Serum
Recurrence
Lung Neoplasms
Biopsy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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A case of radiation fibrosis appearing as mass-like consolidation after SBRT with elevation of serum CEA. / Terashima, Kotaro; Shioyama, Yoshiyuki; Nomoto, Satoshi; Saiji, Ohga; Nonoshita, Takeshi; Ohnishi, Kayoko; Atsumi, Kazushige; Yabuuchi, Hidetake; Hirata, Hideki; Honda, Hiroshi.

In: Case Reports in Medicine, Vol. 2010, 986706, 01.01.2010.

Research output: Contribution to journalArticle

Terashima, Kotaro ; Shioyama, Yoshiyuki ; Nomoto, Satoshi ; Saiji, Ohga ; Nonoshita, Takeshi ; Ohnishi, Kayoko ; Atsumi, Kazushige ; Yabuuchi, Hidetake ; Hirata, Hideki ; Honda, Hiroshi. / A case of radiation fibrosis appearing as mass-like consolidation after SBRT with elevation of serum CEA. In: Case Reports in Medicine. 2010 ; Vol. 2010.
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AU - Nonoshita, Takeshi

AU - Ohnishi, Kayoko

AU - Atsumi, Kazushige

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AU - Honda, Hiroshi

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