A Case of Recurrent Ischemic Stroke due to Intravascular Lymphomatosis, Undiagnosed by Random Skin Biopsy and Brain Imaging

Yuichiro Ohya, Masato Osaki, Shouta Sakai, Shunsuke Kimura, Tatsuro Shimogamo, Tetsuro Ago, Takanari Kitazono, Shuji Arakawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Intravascular lymphoma (IVL) is a rare disease characterized by the proliferation of lymphoma cells in the lumen of the small blood vessels. Although early diagnosis of IVL is important to prolong survival of the patients, its atypical symptoms and clinical course often delay its diagnosis. More than half of the patients are diagnosed at autopsy. We report a 68-year-old man who presented with transient ideomotor apraxia and mildly elevated soluble interleukin-2 receptor levels. He was initially diagnosed with aortogenic embolic stroke. He developed rapidly progressive neurological manifestations with enlargement of brain lesions on brain computed tomography and magnetic resonance imaging and died 3 months after symptom onset. The diagnosis of IVL could not be made by random skin biopsy, but was finally made at autopsy. For the early diagnosis, sufficient random skin biopsy or brain biopsy should be planned when suspected.

Original languageEnglish
Pages (from-to)234-240
Number of pages7
JournalCase Reports in Neurology
Volume9
Issue number3
DOIs
Publication statusPublished - Jan 1 2017

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Neuroimaging
Lymphoma
Stroke
Biopsy
Skin
Early Diagnosis
Autopsy
Brain
Ideomotor Apraxia
Interleukin-2 Receptors
Rare Diseases
Neurologic Manifestations
Blood Vessels
Tomography
Magnetic Resonance Imaging
Cell Proliferation
Survival

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

A Case of Recurrent Ischemic Stroke due to Intravascular Lymphomatosis, Undiagnosed by Random Skin Biopsy and Brain Imaging. / Ohya, Yuichiro; Osaki, Masato; Sakai, Shouta; Kimura, Shunsuke; Shimogamo, Tatsuro; Ago, Tetsuro; Kitazono, Takanari; Arakawa, Shuji.

In: Case Reports in Neurology, Vol. 9, No. 3, 01.01.2017, p. 234-240.

Research output: Contribution to journalArticle

Ohya, Yuichiro ; Osaki, Masato ; Sakai, Shouta ; Kimura, Shunsuke ; Shimogamo, Tatsuro ; Ago, Tetsuro ; Kitazono, Takanari ; Arakawa, Shuji. / A Case of Recurrent Ischemic Stroke due to Intravascular Lymphomatosis, Undiagnosed by Random Skin Biopsy and Brain Imaging. In: Case Reports in Neurology. 2017 ; Vol. 9, No. 3. pp. 234-240.
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