A case of refractory adult-onset Still's disease with high serum interleukin-18 levels treated with monitoring of serum levels of cyclosporine.

Yoshiro Horai, Atsuko Koyama, Tomoya Miyamura, Akie Hirata, Masataka Nakamura, Hitoshi Ando, Soichiro Takahama, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu

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1 Citation (Scopus)

Abstract

We report the case of a 31-year-old woman who developed adult-onset Still's disease (AOSD) with a high level of serum interleukin (IL)-18. Although treated with high dose steroids, she suffered repeated remissions and her condition deteriorated. After we administered oral cyclosporine A (CsA), 200 mg/d, monitoring C2 and trough levels, her symptoms improved significantly. We decreased the dose of methylprednisolone slowly without noting a relapse. The use of CsA accompanied by C2 and trough level monitoring should be considered for refractory AOSD patients with high levels of serum IL-18.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume103
Issue number1
Publication statusPublished - Jan 1 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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