A case of sarcoidosis and idiopathic thrombocytopenic purpura accompanied with invasive pulmonary aspergillosis

Takako Nakano, Satoru Fukuyama, Koji Inoue, Hiromasa Inoue, Naoki Hagimoto, Masaki Fujita, Kazuyoshi Kuwano, Nobuyuki Hara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 54-year-old woman with a 21-year history of sarcoidosis was admitted to our hospital with dyspnea on exertion, weight loss, and the appearance of consolidation in chest radiographs. The serum level of soluble IL-2 receptor was high, and CT findings demonstrated mediastinal, hilar and abdominal lymphadenopathy. The histological findings of subpleural consolidation in a transbronchial lung biopsy of the left lung showed giant cells; and those of a CT-assisted biopsy of a retroperitoneal lymph node revealed non-caseous epithelioid cell granulomas. After the biopsy, severe thrombocytopenia (6,000/microliter) developed. With prednisolone treatment, the platelet count rose to normal and the subpleural consolidation on chest radiography was improved. Five weeks later, the had a productive cough with fever, rapidly progressive cavitary lesions and consolidation on chest radiography. Aspergillus fumigatus was detected in the sputum by PCR, and Aspergillus antigen was detected in the serum. She died of progressive respiratory failure, in spite of therapy with amphotericin B and itraconazole. We report a rare case of sarcoidosis and idiopathic thrombocytopenic purpura accompanied with invasive pulmonary aspergillosis.

Original languageEnglish
Pages (from-to)945-949
Number of pages5
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume40
Issue number12
Publication statusPublished - Jan 1 2002

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Invasive Pulmonary Aspergillosis
Idiopathic Thrombocytopenic Purpura
Sarcoidosis
Thorax
Biopsy
Radiography
Epithelioid Cells
Lung
Aspergillus fumigatus
Itraconazole
Interleukin-2 Receptors
Amphotericin B
Giant Cells
Aspergillus
Prednisolone
Granuloma
Sputum
Serum
Platelet Count
Cough

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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A case of sarcoidosis and idiopathic thrombocytopenic purpura accompanied with invasive pulmonary aspergillosis. / Nakano, Takako; Fukuyama, Satoru; Inoue, Koji; Inoue, Hiromasa; Hagimoto, Naoki; Fujita, Masaki; Kuwano, Kazuyoshi; Hara, Nobuyuki.

In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, Vol. 40, No. 12, 01.01.2002, p. 945-949.

Research output: Contribution to journalArticle

Nakano, Takako ; Fukuyama, Satoru ; Inoue, Koji ; Inoue, Hiromasa ; Hagimoto, Naoki ; Fujita, Masaki ; Kuwano, Kazuyoshi ; Hara, Nobuyuki. / A case of sarcoidosis and idiopathic thrombocytopenic purpura accompanied with invasive pulmonary aspergillosis. In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2002 ; Vol. 40, No. 12. pp. 945-949.
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