A case of scirrhous gastric carcinoma with peritoneal dissemination which was treated by curative gastrectomy after S-1/CDDP chemotherapy

Tomonori Akagi, Tsuyoshi Etoh, Hidetoshi Eguchi, Kazuaki Hiroishi, Yoshitake Ueda, Kazuhiro Yasuda, Tsuyoshi Noguchi, Norio Shiraishi, Seigo Kitano

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Abstract

The present patient was a 53-year-old female diagnosed as gastric cancer with peritoneal dissemination by staging laparoscopy. She was treated with chemotherapy using S-1 (80 mg/body/day) and CDDP (80 mg/body/day, day 8) administered for 3 weeks followed by a drug-free 2 weeks, in five-week courses. Stable disease (SD) was obtained after six courses, and then she underwent second-staging laparoscopy. Because of disappearing peritoneal disseminated nodules both macroscopically and histologically, she underwent curative total gastrectomy with D2 lymph node dissection and reconstruction by the Roux-en Y method. The postoperative pathological findings showed T2 (se) N1M0, stage IIIa and chemotherapy effective evaluation demonstrated Grade 1b. Postoperatively, S-1/CDDP therapy was carried out, after two cycles she suffered from anorexia, and then S-1 only was given. Fourteen months later, peritoneal dissemination developed. Despite changes in the regimen such as docetaxel or CPT-11, she died 23 months after the initial gastrectomy.

Original languageEnglish
Pages (from-to)1573-1577
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume37
Issue number8
Publication statusPublished - Aug 15 2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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