A case of secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome, complicated with disseminated M. abscessus infection

Yukari Asai, Hiroshi Ouchi, Tukasa Ohosima, Ryuji Nakano, Yujiro Yamano, Ichiro Inoshima, Takuji Yamauchi, Satoshi Fukuyama, Hiromasa Inoue, Yoichi Nakanishi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A 27-year-old man was admitted to our hospital complaining of a persistent high fever since August 2007. Chest radiography showed infiltration shadows in the right lower lung field. Chest CT revealed scattered small nodular shadows and patchy consolidations in the right lower lobe. He was diagnosed as secondary pulmonary alveolar proteinosis (sPAP) associated with myelodysplastic syndrome (MDS), confirmed by video-assisted thoracic surgery (VATS) and bone marrow aspiration. Sera were negative for anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody. He developed a subcutaneous abscess and meningitis caused by M. absessus after VATS. After a long-course of antibiotic therapy, an allogenic peripheral blood stem cell transplantation was performed. But he died of graft versus host disease and M. abscessus sepsis 87 days after transplantation.

Original languageEnglish
Pages (from-to)1120-1125
Number of pages6
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume47
Issue number12
Publication statusPublished - Dec 2009

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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