Abstract
We report a case of advanced hepatocellular carcinoma (HCC) with right atrial tumor thrombus treated by interferon (IFN)-combinated chemotherapies and second look operation. A case was a 56-year-old man who had right upper abdominal and back pain. The abdominal CT revealed an early enhanced lesion in the posterior segment of the liver with right atrial tumor thrombus. The patient underwent 2 courses of IFN-β/adriamycin combination therapy and followed by surgical resection. Due to severe congestive live, we only surgically resected tumor thrombi at right atrium, inferior vena cava, and right hepatic vein. Additionally, we closed posterior branch and right hepatic vein to prevent from a tumor progression. Following 16 months of IFN/5-FU and IFN/S-1 therapy, we performed a right posterior sectionectomy of the liver. Twelve months after the second operation, liver tumor relapsed and we performed transcatheter arterial chemoembolizatin, followed by IFN-combinateted chemotherapies. Thereafter, we continued chemotherapy for 14 months. The tumor progressed into the bile duct, and he died after 3 years and 8 months from the initial treatment. The case suggests that some patients with HCC with major vascular invasion and tumor thrombus can gain a long-term survival by multifocal treatment including surgery and chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 2472-2474 |
| Number of pages | 3 |
| Journal | Gan to kagaku ryoho. Cancer & chemotherapy |
| Volume | 38 |
| Issue number | 12 |
| Publication status | Published - Nov 2011 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
[A case of successful second look operation for hepatocellular carcinoma with right atrial tumor thrombus]. / Monden, Kazuyuki; Kobayashi, Shogo; Wada, Hiroshi; Marubashi, Shigeru; Eguchi, Hidetoshi; Tanemura, Masahiro; Umeshita, Koji; Mori, Masaki; Doki, Yuichiro; Nagano, Hiroaki.
In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 38, No. 12, 11.2011, p. 2472-2474.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - [A case of successful second look operation for hepatocellular carcinoma with right atrial tumor thrombus].
AU - Monden, Kazuyuki
AU - Kobayashi, Shogo
AU - Wada, Hiroshi
AU - Marubashi, Shigeru
AU - Eguchi, Hidetoshi
AU - Tanemura, Masahiro
AU - Umeshita, Koji
AU - Mori, Masaki
AU - Doki, Yuichiro
AU - Nagano, Hiroaki
PY - 2011/11
Y1 - 2011/11
N2 - We report a case of advanced hepatocellular carcinoma (HCC) with right atrial tumor thrombus treated by interferon (IFN)-combinated chemotherapies and second look operation. A case was a 56-year-old man who had right upper abdominal and back pain. The abdominal CT revealed an early enhanced lesion in the posterior segment of the liver with right atrial tumor thrombus. The patient underwent 2 courses of IFN-β/adriamycin combination therapy and followed by surgical resection. Due to severe congestive live, we only surgically resected tumor thrombi at right atrium, inferior vena cava, and right hepatic vein. Additionally, we closed posterior branch and right hepatic vein to prevent from a tumor progression. Following 16 months of IFN/5-FU and IFN/S-1 therapy, we performed a right posterior sectionectomy of the liver. Twelve months after the second operation, liver tumor relapsed and we performed transcatheter arterial chemoembolizatin, followed by IFN-combinateted chemotherapies. Thereafter, we continued chemotherapy for 14 months. The tumor progressed into the bile duct, and he died after 3 years and 8 months from the initial treatment. The case suggests that some patients with HCC with major vascular invasion and tumor thrombus can gain a long-term survival by multifocal treatment including surgery and chemotherapy.
AB - We report a case of advanced hepatocellular carcinoma (HCC) with right atrial tumor thrombus treated by interferon (IFN)-combinated chemotherapies and second look operation. A case was a 56-year-old man who had right upper abdominal and back pain. The abdominal CT revealed an early enhanced lesion in the posterior segment of the liver with right atrial tumor thrombus. The patient underwent 2 courses of IFN-β/adriamycin combination therapy and followed by surgical resection. Due to severe congestive live, we only surgically resected tumor thrombi at right atrium, inferior vena cava, and right hepatic vein. Additionally, we closed posterior branch and right hepatic vein to prevent from a tumor progression. Following 16 months of IFN/5-FU and IFN/S-1 therapy, we performed a right posterior sectionectomy of the liver. Twelve months after the second operation, liver tumor relapsed and we performed transcatheter arterial chemoembolizatin, followed by IFN-combinateted chemotherapies. Thereafter, we continued chemotherapy for 14 months. The tumor progressed into the bile duct, and he died after 3 years and 8 months from the initial treatment. The case suggests that some patients with HCC with major vascular invasion and tumor thrombus can gain a long-term survival by multifocal treatment including surgery and chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=84858816259&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858816259&partnerID=8YFLogxK
M3 - Article
C2 - 22202417
AN - SCOPUS:84858816259
VL - 38
SP - 2472
EP - 2474
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
SN - 0385-0684
IS - 12
ER -