A case of suprasellar ganglioglioma arising from the genu‒rostrum of the corpus callosum composed of tumor cells in various stages of neuronal differentiation

Yusuke Funakoshi, Yoshihiro Natori, Satoshi Suzuki, Toru Iwaki, Naoyuki Imamoto, Tetsuhisa Yamada, Daisuke Inoue, Megumu Mori, Satoshi Matsuo, Katsuma Iwaki

Research output: Contribution to journalArticle

Abstract

Ganglioglioma was first described by Courville in 1930 and defined as a tumor containing both neuronal and glial components. Gangliogliomas account for 0.3‒1.3% of all primary brain tumors. These tumors appear most commonly in the temporal lobe. Suprasellar gangliogliomas are quite rare, and only 15 cases have been reported to date. The suprasellar region is divided into the optic nerve/optic chiasma/hypothalamus and the corpus callosum/septum pellucidum. Previous reports have shown that suprasellar gangliogliomas are localized primarily in the optic nerve/optic chiasma/hypothalamus region. No tumors have been described in the corpus callosum/septum pellucidum region. Here we present a case of suprasellar ganglioglioma in a 21‒year‒old woman. She presented with a gradually increasing headache over a period of 1 year. She was diagnosed with a brain tumor by her previous doctor, and was subsequently introduced to our department. CT and MRI demonstrated a suprasellar lesion with coarse calcification. The lesion displaced the third ventricle backward, and the bilateral lateral ventricles laterally, and obstructed the foramen of Monro, causing obstructive hydrocephalus. The lesion was completely removed by an interhemispheric approach. Because strong adhesion was observed between the lesion and the corpus callosum, the lesion probably arose from a site around the corpus callosum. Histopathological diagnosis was ganglioglioma. However, the neuronal component consisted of tumor cells of diverse stages of neuronal differentination, including well‒differentiated ganglion cells, neurocytic cells, and small neuroblastic cells. To the best of our knowledge, this case is unique in both the location and differentiation status of the neuronal component.

Original languageEnglish
Pages (from-to)362-368
Number of pages7
JournalJapanese Journal of Neurosurgery
Volume26
Issue number5
DOIs
Publication statusPublished - Jan 1 2017

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Ganglioglioma
Corpus Callosum
Septum Pellucidum
Optic Chiasm
Neoplasms
Optic Nerve
Brain Neoplasms
Hypothalamus
Cerebral Ventricles
Third Ventricle
Lateral Ventricles
Temporal Lobe
Hydrocephalus
Neuroglia
Ganglia
Headache

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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A case of suprasellar ganglioglioma arising from the genu‒rostrum of the corpus callosum composed of tumor cells in various stages of neuronal differentiation. / Funakoshi, Yusuke; Natori, Yoshihiro; Suzuki, Satoshi; Iwaki, Toru; Imamoto, Naoyuki; Yamada, Tetsuhisa; Inoue, Daisuke; Mori, Megumu; Matsuo, Satoshi; Iwaki, Katsuma.

In: Japanese Journal of Neurosurgery, Vol. 26, No. 5, 01.01.2017, p. 362-368.

Research output: Contribution to journalArticle

Funakoshi, Yusuke ; Natori, Yoshihiro ; Suzuki, Satoshi ; Iwaki, Toru ; Imamoto, Naoyuki ; Yamada, Tetsuhisa ; Inoue, Daisuke ; Mori, Megumu ; Matsuo, Satoshi ; Iwaki, Katsuma. / A case of suprasellar ganglioglioma arising from the genu‒rostrum of the corpus callosum composed of tumor cells in various stages of neuronal differentiation. In: Japanese Journal of Neurosurgery. 2017 ; Vol. 26, No. 5. pp. 362-368.
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abstract = "Ganglioglioma was first described by Courville in 1930 and defined as a tumor containing both neuronal and glial components. Gangliogliomas account for 0.3‒1.3{\%} of all primary brain tumors. These tumors appear most commonly in the temporal lobe. Suprasellar gangliogliomas are quite rare, and only 15 cases have been reported to date. The suprasellar region is divided into the optic nerve/optic chiasma/hypothalamus and the corpus callosum/septum pellucidum. Previous reports have shown that suprasellar gangliogliomas are localized primarily in the optic nerve/optic chiasma/hypothalamus region. No tumors have been described in the corpus callosum/septum pellucidum region. Here we present a case of suprasellar ganglioglioma in a 21‒year‒old woman. She presented with a gradually increasing headache over a period of 1 year. She was diagnosed with a brain tumor by her previous doctor, and was subsequently introduced to our department. CT and MRI demonstrated a suprasellar lesion with coarse calcification. The lesion displaced the third ventricle backward, and the bilateral lateral ventricles laterally, and obstructed the foramen of Monro, causing obstructive hydrocephalus. The lesion was completely removed by an interhemispheric approach. Because strong adhesion was observed between the lesion and the corpus callosum, the lesion probably arose from a site around the corpus callosum. Histopathological diagnosis was ganglioglioma. However, the neuronal component consisted of tumor cells of diverse stages of neuronal differentination, including well‒differentiated ganglion cells, neurocytic cells, and small neuroblastic cells. To the best of our knowledge, this case is unique in both the location and differentiation status of the neuronal component.",
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