A case of therapy-related myelodysplastic syndrome after oral cancer therapy

Mioko Matsuo, Rina Jiromaru

Research output: Contribution to journalArticlepeer-review

Abstract

Therapy-related myelodysplastic syndrome (t-MDS) is a disease involving abnormal hematocytes caused by treatment for previous malignant tumours. We describe a case of t-MDS that developed after treatment for head and neck cancer. A 71-year-old man underwent chemoradiotherapy for the recurrence of oral cancer. The radiation dose was 60 Gy and combination chemotherapy was cisplatin(240 mg/body, 160 mg/m2). Pancytopenia occurred 3 months after chemoradiotherapy was completed, and t-MDS was diagnosed. The patient is living at the present 20 months after the onset of t-MDS with administration of a long-acting erythropoiesis-stimulating agent as supportive therapy for anemia. When pancytopenia is encountered after head and neck cancer treatment, early consultation with an expert is important in view of the possibility of t-MDS. Early start of supportive therapy after the detection of t-MDS helps maintain and improve the patient’s quality of life.

Original languageEnglish
Pages (from-to)388-392
Number of pages5
JournalJapanese Journal of Head and Neck Cancer
Volume43
Issue number3
DOIs
Publication statusPublished - Jan 1 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Oncology

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