A case of tuberculosis pleuritis with high serum soluble IL-2 receptor

Yuya Fujiwara, Naotsugu Takahashi, Hiroshi Koto, Hiroko Nogami, Kinji Yokota, Terufumi Shimoda, Shunsuke Shoji, Sankei Nishima, Chiharu Kubo

Research output: Contribution to journalArticle

Abstract

A 56-year-old man was admitted to our hospital because of bilateral pleural effusion. Computed tomography revealed solitary mediastinal lymphadenopathy, splenomegaly and a small amount of ascites. No lung parenchymal lesion was seen. Although lymphocyte predominance without atypia and a high adenocine deaminase concentration in the pleural fluid were compatible with tuberculous pleurisy, no mycobacteria could be detected either with Ziehl-Nielsen stain or with PCR. Because the serum soluble interleukin 2 receptor (sIL-2 R) level was unexpectedly high (> 8,000 U/ml), and a level not previously reported in benign diseases, we performed thoracoscopy- and mediastinoscopy-assisted biopsies, both of which eventually confirmed the diagnosis of tuberculosis. After a 4-drug anti-tuberculous regimen was initiated, pleural effusion and ascites subsided, with a marked decrease in the sIL-2R level. This case indicates that in tuberculous pleurisy, serum sIL-2R can rise to a level suggestive of hematological malignancies, it and also illustrates the validity of thoracoscopy-assisted pleural biopsy in such situations.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume42
Issue number2
Publication statusPublished - Jan 1 2004

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Pleural Tuberculosis
Thoracoscopy
Pleurisy
Interleukin-2 Receptors
Pleural Effusion
Ascites
Tuberculosis
Mediastinoscopy
Biopsy
Splenomegaly
Hematologic Neoplasms
Mycobacterium
Serum
Coloring Agents
Tomography
Lymphocytes
Polymerase Chain Reaction
Lung
Pharmaceutical Preparations
Lymphadenopathy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

A case of tuberculosis pleuritis with high serum soluble IL-2 receptor. / Fujiwara, Yuya; Takahashi, Naotsugu; Koto, Hiroshi; Nogami, Hiroko; Yokota, Kinji; Shimoda, Terufumi; Shoji, Shunsuke; Nishima, Sankei; Kubo, Chiharu.

In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, Vol. 42, No. 2, 01.01.2004, p. 191-194.

Research output: Contribution to journalArticle

Fujiwara, Y, Takahashi, N, Koto, H, Nogami, H, Yokota, K, Shimoda, T, Shoji, S, Nishima, S & Kubo, C 2004, 'A case of tuberculosis pleuritis with high serum soluble IL-2 receptor', Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, vol. 42, no. 2, pp. 191-194.
Fujiwara Y, Takahashi N, Koto H, Nogami H, Yokota K, Shimoda T et al. A case of tuberculosis pleuritis with high serum soluble IL-2 receptor. Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2004 Jan 1;42(2):191-194.
Fujiwara, Yuya ; Takahashi, Naotsugu ; Koto, Hiroshi ; Nogami, Hiroko ; Yokota, Kinji ; Shimoda, Terufumi ; Shoji, Shunsuke ; Nishima, Sankei ; Kubo, Chiharu. / A case of tuberculosis pleuritis with high serum soluble IL-2 receptor. In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2004 ; Vol. 42, No. 2. pp. 191-194.
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