A case of unilateral pustular pyoderma gangrenosum

Yuka Morioka, Gaku Tsuji, Saho Kawahara, Yukihiro Mizote, Takeshi Nakahara, Uchi Hiroshi, Masutaka Furue

Research output: Contribution to journalArticle

Abstract

A 44-year-old male who had no medical history was admitted to our hospital complaining of a four-month history of sudden-onset multiple ulcers on the left thigh. Physical examination revealed ulcerative lesions with multiple small pustules on the left thigh. Laboratory examination showed an increased number of leukocytes (13,610/mm3) with 93.2% neutrophils and elevated CRP (4.35 mg/dL). Histological examination showed neutrophilic infiltration into the mid- to lower dermis, especially around the hair follicles. The diagnosis of unilateral pustular pyoderma gangrenosum was made. Systemic prednisolone, cyclosporine A, and sulfasalazine were initiated after treatment with mini pulse steroid therapy (methylprednisolone at 500 mg/day for five days). Despite the decreased inflammatory response, the patient suffered from multiple painful ulcers, which were successfully treated with negative-pressure wound therapy (NPWT) starting 66 days after admission. Rapid re-epithelization and pain reduction could be achieved with NPWT in this case.

Original languageEnglish
Pages (from-to)136-139
Number of pages4
JournalNishinihon Journal of Dermatology
Volume79
Issue number2
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Negative-Pressure Wound Therapy
Pyoderma Gangrenosum
Thigh
Ulcer
Sulfasalazine
Hair Follicle
Methylprednisolone
Dermis
Prednisolone
Leukocyte Count
Cyclosporine
Physical Examination
Neutrophils
Steroids
Pain
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

A case of unilateral pustular pyoderma gangrenosum. / Morioka, Yuka; Tsuji, Gaku; Kawahara, Saho; Mizote, Yukihiro; Nakahara, Takeshi; Hiroshi, Uchi; Furue, Masutaka.

In: Nishinihon Journal of Dermatology, Vol. 79, No. 2, 01.01.2017, p. 136-139.

Research output: Contribution to journalArticle

Morioka, Yuka ; Tsuji, Gaku ; Kawahara, Saho ; Mizote, Yukihiro ; Nakahara, Takeshi ; Hiroshi, Uchi ; Furue, Masutaka. / A case of unilateral pustular pyoderma gangrenosum. In: Nishinihon Journal of Dermatology. 2017 ; Vol. 79, No. 2. pp. 136-139.
@article{c4d3bf588f3e466ab326d88c30daea41,
title = "A case of unilateral pustular pyoderma gangrenosum",
abstract = "A 44-year-old male who had no medical history was admitted to our hospital complaining of a four-month history of sudden-onset multiple ulcers on the left thigh. Physical examination revealed ulcerative lesions with multiple small pustules on the left thigh. Laboratory examination showed an increased number of leukocytes (13,610/mm3) with 93.2{\%} neutrophils and elevated CRP (4.35 mg/dL). Histological examination showed neutrophilic infiltration into the mid- to lower dermis, especially around the hair follicles. The diagnosis of unilateral pustular pyoderma gangrenosum was made. Systemic prednisolone, cyclosporine A, and sulfasalazine were initiated after treatment with mini pulse steroid therapy (methylprednisolone at 500 mg/day for five days). Despite the decreased inflammatory response, the patient suffered from multiple painful ulcers, which were successfully treated with negative-pressure wound therapy (NPWT) starting 66 days after admission. Rapid re-epithelization and pain reduction could be achieved with NPWT in this case.",
author = "Yuka Morioka and Gaku Tsuji and Saho Kawahara and Yukihiro Mizote and Takeshi Nakahara and Uchi Hiroshi and Masutaka Furue",
year = "2017",
month = "1",
day = "1",
doi = "10.2336/nishinihonhifu.79.136",
language = "English",
volume = "79",
pages = "136--139",
journal = "Nishinihon Journal of Dermatology",
issn = "0386-9784",
publisher = "Kyushu University, Faculty of Science",
number = "2",

}

TY - JOUR

T1 - A case of unilateral pustular pyoderma gangrenosum

AU - Morioka, Yuka

AU - Tsuji, Gaku

AU - Kawahara, Saho

AU - Mizote, Yukihiro

AU - Nakahara, Takeshi

AU - Hiroshi, Uchi

AU - Furue, Masutaka

PY - 2017/1/1

Y1 - 2017/1/1

N2 - A 44-year-old male who had no medical history was admitted to our hospital complaining of a four-month history of sudden-onset multiple ulcers on the left thigh. Physical examination revealed ulcerative lesions with multiple small pustules on the left thigh. Laboratory examination showed an increased number of leukocytes (13,610/mm3) with 93.2% neutrophils and elevated CRP (4.35 mg/dL). Histological examination showed neutrophilic infiltration into the mid- to lower dermis, especially around the hair follicles. The diagnosis of unilateral pustular pyoderma gangrenosum was made. Systemic prednisolone, cyclosporine A, and sulfasalazine were initiated after treatment with mini pulse steroid therapy (methylprednisolone at 500 mg/day for five days). Despite the decreased inflammatory response, the patient suffered from multiple painful ulcers, which were successfully treated with negative-pressure wound therapy (NPWT) starting 66 days after admission. Rapid re-epithelization and pain reduction could be achieved with NPWT in this case.

AB - A 44-year-old male who had no medical history was admitted to our hospital complaining of a four-month history of sudden-onset multiple ulcers on the left thigh. Physical examination revealed ulcerative lesions with multiple small pustules on the left thigh. Laboratory examination showed an increased number of leukocytes (13,610/mm3) with 93.2% neutrophils and elevated CRP (4.35 mg/dL). Histological examination showed neutrophilic infiltration into the mid- to lower dermis, especially around the hair follicles. The diagnosis of unilateral pustular pyoderma gangrenosum was made. Systemic prednisolone, cyclosporine A, and sulfasalazine were initiated after treatment with mini pulse steroid therapy (methylprednisolone at 500 mg/day for five days). Despite the decreased inflammatory response, the patient suffered from multiple painful ulcers, which were successfully treated with negative-pressure wound therapy (NPWT) starting 66 days after admission. Rapid re-epithelization and pain reduction could be achieved with NPWT in this case.

UR - http://www.scopus.com/inward/record.url?scp=85020837281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020837281&partnerID=8YFLogxK

U2 - 10.2336/nishinihonhifu.79.136

DO - 10.2336/nishinihonhifu.79.136

M3 - Article

VL - 79

SP - 136

EP - 139

JO - Nishinihon Journal of Dermatology

JF - Nishinihon Journal of Dermatology

SN - 0386-9784

IS - 2

ER -