A case of Zollinger-Ellison syndrome diagnosed three years after ulcer perforation in the third portion of the duodenum

Soichi Itaba, Kuniomi Honda, Kazuhiko Nakamura, Shigetaka Yoshinaga, Naomi Higuchi, Hirotada Akiho, Jyunya Gibo, Yoshiyuki Arita, Tetsuhide Ito, Masao Tanaka, Yumiko Segawa, Tsutomu Iwasa, Ryoichi Takayanagi

Research output: Contribution to journalArticlepeer-review

Abstract

A 61-year-old woman was referred to our hospital for a double balloon endoscopy (DBE) examination of small intestine. She had undergone laparotomy for a perforated ulcer of the 3rd portion in the duodenum 3 years prior to this admission. Esophagogastroduodenoscopy at the previous hospital revealed multiple ulcers in the 2nd and 3rd portions in the duodenum. DBE revealed multiple ulcer scars in the proximal jejunum. Zollinger-Ellison syndrome was suspected from the distribution of the ulcers and scars. Serum gastrin was high and a selective arterial calcium injection test showed a step up of gastrin level only in the gastroduodenal artery area. We diagnosed a gastrinoma located on the ventral side of the 2nd portion of the duodenum from imaging studies. The tumor was extirpated and histologically found to be a neuroendocrine tumor in a lymph node. Serum gastrin level decreased to the normal range a day after surgery.

Original languageEnglish
Pages (from-to)705-710
Number of pages6
JournalJapanese Journal of Gastroenterology
Volume105
Issue number5
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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