A case report of neuroendocrine carcinoma of the stomach with liver metastases curatively resected after neoadjuvant chemotherapy

Kentaro Hokonohara, Akihiro Takata, Takehiro Noda, Hiroshi Imamura, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Hisanori Hatano, Takamichi Komori, Shunji Morita, Takashi Iwazawa, Kenzo Akagi, Shiro Adachi, Keizo Dono

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Abstract

The patient was a 73-year-old male with advanced gastric cancer in the lesser curvature of the antrum. Abdominal computed tomography revealed multiple liver metastases (S5, SB). He was diagnosed with clinical Stage IV gastric cancer (cT3N0M1H1) He received 3 courses of combined neoadjuvant chemotherapy with capecitabine, cisplatin, and trastuzumab because immunostaining indicated the tumor was human epidermal growth factor receptor 2 (HER2)-positive. The therapeutic response as assessed by imaging studies, was partial for the primary lesions and stable for liver metastases. Distal gastrectomy D2 lymph node dissection, and S5 extended subsegmentectomy of the liver were performed. Histopathological findings indicated that both the primary tumor and liver metastases were neuroendocrine carcinoma. The patient declined post-operative adjuvant chemotherapy and he is alive 6 months after the surgery with no evidence of recurrence. Surgery with neoadjuvant chemotherapy appears to be a promising option for advanced gastric cancer with liver metastases.

Original languageEnglish
Pages (from-to)2287-2289
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume41
Issue number12
Publication statusPublished - Nov 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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