A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Koichi Akashi, David Traver, Toshihiro Miyamoto, Irving L. Weissman

Research output: Contribution to journalArticle

1681 Citations (Scopus)

Abstract

Haematopoietic stem cells give rise to progeny that progressively lose self-renewal capacity and become restricted to one lineage. The points at which haematopoietic stem cell-derived progenitors commit to each of the various lineages remain mostly unknown. We have identified a clonogenic common lymphoid progenitor that can differentiate into T, B and natural killer cells but not myeloid cells. Here we report the prospective identification, purification and characterization, using cell-surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Common myeloid progenitors give rise to either megakaryocyte/erythrocyte or granulocyte/macrophage progenitors. Purified progenitors were used to provide a first-pass expression profile of various haematopoiesis-related genes. We propose that the common lymphoid progenitor and common myeloid progenitor populations reflect the earliest branch points between the lymphoid and myeloid lineages, and that the commitment of common myeloid progenitors to either the megakaryocyte/erythrocyte or the granulocyte/macrophage lineages are mutually exclusive events.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalNature
Volume404
Issue number6774
DOIs
Publication statusPublished - Mar 9 2000
Externally publishedYes

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Myeloid Progenitor Cells
Lymphoid Progenitor Cells
Megakaryocytes
Hematopoietic Stem Cells
Erythrocytes
Granulocyte-Macrophage Progenitor Cells
Natural Killer T-Cells
Hematopoiesis
Myeloid Cells
Granulocytes
Flow Cytometry
Macrophages
Population
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. / Akashi, Koichi; Traver, David; Miyamoto, Toshihiro; Weissman, Irving L.

In: Nature, Vol. 404, No. 6774, 09.03.2000, p. 193-197.

Research output: Contribution to journalArticle

Akashi, Koichi ; Traver, David ; Miyamoto, Toshihiro ; Weissman, Irving L. / A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. In: Nature. 2000 ; Vol. 404, No. 6774. pp. 193-197.
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