A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro

Eri Kawata, Eishi Ashihara, Yoko Nakagawa, Takahiro Kiuchi, Mai Ogura, Hisayuku Yao, Kazuki Sakai, Ruriko Tanaka, Rina Nagao, Asumi Yokota, Miki Takeuchi, Shinya Kimura, Hideyo Hirai, Taira Maekawa

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14 Citations (Scopus)

Abstract

Although novel agents effective against malignant mesothelioma (MM) have been developed, the prognosis of patients with MM is still poor. We generated a DNA-chimeric siRNA against polo-like kinase-1 (PLK-1), which was more stable in human serum than the non-chimeric siRNA. The chimeric PLK-1 siRNA inhibited MM cell proliferation through the induction of apoptosis. Next, we investigated the effects of zoledronic acid (ZOL) on MM cells, and found that ZOL also induced apoptosis in MM cells. Furthermore, ZOL augmented the inhibitory effects of the PLK-1 siRNA. In conclusion, combining a PLK-1 siRNA with ZOL treatment is an attractive strategy against MM.

Original languageEnglish
Pages (from-to)245-253
Number of pages9
JournalCancer Letters
Volume294
Issue number2
DOIs
Publication statusPublished - Aug 1 2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Kawata, E., Ashihara, E., Nakagawa, Y., Kiuchi, T., Ogura, M., Yao, H., Sakai, K., Tanaka, R., Nagao, R., Yokota, A., Takeuchi, M., Kimura, S., Hirai, H., & Maekawa, T. (2010). A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro. Cancer Letters, 294(2), 245-253. https://doi.org/10.1016/j.canlet.2010.02.008