A comparative immunohistochemical study of kuru and senile plaques with a special reference to glial reactions at various stages of amyloid plaque formation

M. Miyazono, T. Iwaki, T. Kitamoto, Y. Kaneko, K. Doh-ura, J. Tateishi

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79 Citations (Scopus)

Abstract

The authors examined 10 patients with Gerstmann-Straussler syndrome or Creutzfeldt-Jakob disease and 10 with Alzheimer's disease (AD). Immunohistochemistry using anti-prion protein (PrP) and anti-β/A4 protein (β/A4) coupled with formic acid pretreatment could detect Congophilic and non-Congophilic deposits. Prion protein deposits were classified into five types and compared with types of β/A4 deposits. Kuru plaques with multicentric cores and fine granular deposits were a characteristic feature of PrP deposits. Some types of PrP or β/A4 deposits depend on the anatomic sites. To clarify the relationship of microglia and astrocytes to PrP or β/A4 deposits, double-immunostaining method was performed. In both kuru and senile plaques, microglia were closely linked to the Congophilic plaques. Astrocytes, however, extended their processes toward the plaques even in the non-Congophilic plaques. These observations strongly suggest that similar glial association with plaque formation may be involved in both kuru and senile plaques, although the amyloid core proteins differ.

Original languageEnglish
Pages (from-to)589-598
Number of pages10
JournalAmerican Journal of Pathology
Volume139
Issue number3
Publication statusPublished - Jan 1 1991

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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