A comparative immunohistochemical study of tissue transglutaminase and factor XIIIa in hemangioblastoma

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Abstract

The tissue transglutaminase (tissue TG) is a cross-linking enzyme, which is observed in a subpopulation of erythrocytes, endothelium, and smooth muscle cells of vessels. It consists of the homologous gene with factor XIIIa (F-XIIIa) and keratinocyte transglutaminase. The tissue TG expression was examined by immunostaining in ten hemangioblastomas and immunoblotting in seven, then such expression was compared with the expression of F-XIIIa. The stromal cells showed a diffuse immunoreactivity with tissue TG in all examined tumor tissue specimens. The immunohistochemical profiles of tissue TG were different from those of F-XIIIa, which were mainly localized in either spindle or stellate cells. By immunoblotting, both tissue TG and F-XIIIa were detected in all examined samples. The most characteristic feature of stromal cells was thus found to be the presence of tissue TG and not F-XIIIa. Tissue TG is therefore considered useful in detecting the stromal cells in hemangioblastoma.

Original languageEnglish
Pages (from-to)199-205
Number of pages7
JournalNeuropathology
Volume18
Issue number2
DOIs
Publication statusPublished - Jan 1 1998

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology

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