A comparative study of thallium-201 SPET, carbon-11 methionine PET and fluorine-18 fluorodeoxyglucose PET for the differentiation of astrocytic tumours

Masayuki Sasaki, Yasuo Kuwabara, Tsuyoshi Yoshida, Makoto Nakagawa, Toshimitsu Fukumura, Futoshi Mihara, Takato Morioka, Masashi Fukui, Kouji Masuda

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Abstract

Thallium-201, carbon-11 methionine (MET) and fluorine-18 fluorodeoxyglucose (FDG) have all been used to assess brain tumours. The aim of this study was to determine which of these tracers are of use for evaluating the histological grade and the extent of astrocytoma. 201Tl single-photon emission tomography (SPET), MET positron emission tomography (PET) and FDG PET were all performed in 23 patients (13 men, 10 women) with newly diagnosed astrocytic tumours [seven with astrocytoma (grade II), ten with anaplastic astrocytoma (grade III) and six with glioblastoma (grade IV)]. The 201Tl uptake of the tumours was evaluated by a lesion-to-normal region count ratio. Both MET and FDG uptake of the tumours was evaluated by a semiquantitative analysis using the standardized uptake value. 201Tl uptake was found to increase in rank order with histological grade and was significantly different among the three groups (grade II: 1.51 ± 0.36; grade III: 2.58 ± 1.50; grade IV: 7.65 ± 3.84). MET uptake in grade II (1.49 ± 0.44) was also significantly lower than that in both grade III (3.29 ± 1.44) and grade IV (3.20 ± 0.92). FDG uptake was not significantly different among the three groups (grade II: 2.90 ± 0.45; grade III: 3.86 ± 1.56; grade IV: 3.57 ± 0.83). No significant correlation was observed between 201Tl uptake and either MET uptake or FDG uptake. In most patients, the extent of the increased MET uptake was the largest while that of the increased FDG uptake was the smallest. In patients with positive 201Tl uptake, the extent of the 201Tl uptake was equal to or smaller than that of gadolinium enhancement. For evaluation of histological grade of astrocytic tumours. 201Tl is therefore considered to be useful though the 201Tl uptake in some grade III astrocytomas was not different from that in grade II astrocytomas. MET was found to be highly useful for detecting astrocytomas, for differentiating between benign and malignant astrocytomas, and for evaluating the extent of astrocytomas; however, it was not sufficiently useful permit evaluation of the histological grade. FDG was not found to be useful either for evaluating the histological grade or for differentiating between benign and malignant astrocytomas.

Original languageEnglish
Pages (from-to)1261-1269
Number of pages9
JournalEuropean Journal of Nuclear Medicine
Volume25
Issue number9
DOIs
Publication statusPublished - Oct 12 1998

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Thallium
Astrocytoma
Fluorodeoxyglucose F18
Photons
Positron-Emission Tomography
Tomography
Methionine
Neoplasms
carbon-11 methionine
Gadolinium
Glioblastoma
Brain Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

A comparative study of thallium-201 SPET, carbon-11 methionine PET and fluorine-18 fluorodeoxyglucose PET for the differentiation of astrocytic tumours. / Sasaki, Masayuki; Kuwabara, Yasuo; Yoshida, Tsuyoshi; Nakagawa, Makoto; Fukumura, Toshimitsu; Mihara, Futoshi; Morioka, Takato; Fukui, Masashi; Masuda, Kouji.

In: European Journal of Nuclear Medicine, Vol. 25, No. 9, 12.10.1998, p. 1261-1269.

Research output: Contribution to journalArticle

Sasaki, Masayuki ; Kuwabara, Yasuo ; Yoshida, Tsuyoshi ; Nakagawa, Makoto ; Fukumura, Toshimitsu ; Mihara, Futoshi ; Morioka, Takato ; Fukui, Masashi ; Masuda, Kouji. / A comparative study of thallium-201 SPET, carbon-11 methionine PET and fluorine-18 fluorodeoxyglucose PET for the differentiation of astrocytic tumours. In: European Journal of Nuclear Medicine. 1998 ; Vol. 25, No. 9. pp. 1261-1269.
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abstract = "Thallium-201, carbon-11 methionine (MET) and fluorine-18 fluorodeoxyglucose (FDG) have all been used to assess brain tumours. The aim of this study was to determine which of these tracers are of use for evaluating the histological grade and the extent of astrocytoma. 201Tl single-photon emission tomography (SPET), MET positron emission tomography (PET) and FDG PET were all performed in 23 patients (13 men, 10 women) with newly diagnosed astrocytic tumours [seven with astrocytoma (grade II), ten with anaplastic astrocytoma (grade III) and six with glioblastoma (grade IV)]. The 201Tl uptake of the tumours was evaluated by a lesion-to-normal region count ratio. Both MET and FDG uptake of the tumours was evaluated by a semiquantitative analysis using the standardized uptake value. 201Tl uptake was found to increase in rank order with histological grade and was significantly different among the three groups (grade II: 1.51 ± 0.36; grade III: 2.58 ± 1.50; grade IV: 7.65 ± 3.84). MET uptake in grade II (1.49 ± 0.44) was also significantly lower than that in both grade III (3.29 ± 1.44) and grade IV (3.20 ± 0.92). FDG uptake was not significantly different among the three groups (grade II: 2.90 ± 0.45; grade III: 3.86 ± 1.56; grade IV: 3.57 ± 0.83). No significant correlation was observed between 201Tl uptake and either MET uptake or FDG uptake. In most patients, the extent of the increased MET uptake was the largest while that of the increased FDG uptake was the smallest. In patients with positive 201Tl uptake, the extent of the 201Tl uptake was equal to or smaller than that of gadolinium enhancement. For evaluation of histological grade of astrocytic tumours. 201Tl is therefore considered to be useful though the 201Tl uptake in some grade III astrocytomas was not different from that in grade II astrocytomas. MET was found to be highly useful for detecting astrocytomas, for differentiating between benign and malignant astrocytomas, and for evaluating the extent of astrocytomas; however, it was not sufficiently useful permit evaluation of the histological grade. FDG was not found to be useful either for evaluating the histological grade or for differentiating between benign and malignant astrocytomas.",
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N2 - Thallium-201, carbon-11 methionine (MET) and fluorine-18 fluorodeoxyglucose (FDG) have all been used to assess brain tumours. The aim of this study was to determine which of these tracers are of use for evaluating the histological grade and the extent of astrocytoma. 201Tl single-photon emission tomography (SPET), MET positron emission tomography (PET) and FDG PET were all performed in 23 patients (13 men, 10 women) with newly diagnosed astrocytic tumours [seven with astrocytoma (grade II), ten with anaplastic astrocytoma (grade III) and six with glioblastoma (grade IV)]. The 201Tl uptake of the tumours was evaluated by a lesion-to-normal region count ratio. Both MET and FDG uptake of the tumours was evaluated by a semiquantitative analysis using the standardized uptake value. 201Tl uptake was found to increase in rank order with histological grade and was significantly different among the three groups (grade II: 1.51 ± 0.36; grade III: 2.58 ± 1.50; grade IV: 7.65 ± 3.84). MET uptake in grade II (1.49 ± 0.44) was also significantly lower than that in both grade III (3.29 ± 1.44) and grade IV (3.20 ± 0.92). FDG uptake was not significantly different among the three groups (grade II: 2.90 ± 0.45; grade III: 3.86 ± 1.56; grade IV: 3.57 ± 0.83). No significant correlation was observed between 201Tl uptake and either MET uptake or FDG uptake. In most patients, the extent of the increased MET uptake was the largest while that of the increased FDG uptake was the smallest. In patients with positive 201Tl uptake, the extent of the 201Tl uptake was equal to or smaller than that of gadolinium enhancement. For evaluation of histological grade of astrocytic tumours. 201Tl is therefore considered to be useful though the 201Tl uptake in some grade III astrocytomas was not different from that in grade II astrocytomas. MET was found to be highly useful for detecting astrocytomas, for differentiating between benign and malignant astrocytomas, and for evaluating the extent of astrocytomas; however, it was not sufficiently useful permit evaluation of the histological grade. FDG was not found to be useful either for evaluating the histological grade or for differentiating between benign and malignant astrocytomas.

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