A comparison of glandular involvement between chronic graft-versus-host disease and Sjögren's syndrome

Akiko Hiroki, Seiji Nakamura, Masanori Shinohara, Hisashi Gondo, Yukiko Ohyama, Shin Hayashi, Mine Harada, Yoshiyuki Niho, Masuichiro Oka

Research output: Contribution to journalArticle

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Abstract

Patients with chronic graft-versus-host disease (cGVHD) occasionally suffer from symptoms of xerostomia and xerophthalmia, which are also features of Sjögren's syndrome (SS). To identify differences in the glandular involvement between cGVHD and SS, we measured the proportions of infiltrating lymphocyte subsets and the expression of HLA-DR antigen and cell adhesion molecules in labial salivary glands (LSG). In cGVHD, more than 90% of the infiltrating lymphocytes were T cells with a slight predominance of CD8+ over CD4+ cells. In SS, CD4+ cells were predominant, and B cells accounted for 10-30% of the infiltrating lymphocytes. Ductal epithelial cells associated with lymphocytic infiltration expressed HLA-DR antigen in both cGVHD and SS. In SS alone, HLA-DR antigen expression also occurred without associated lymphocytic infiltration. The expression of adhesion molecules on ductal epithelial cells, especially vascular cell adhesion molecule-1, was more intense in SS than in cGVHD, while that on endothelial cells was similar in cGVHD and SS. These data suggest that the pathogenesis of glandular involvement of cGVHD is different from that of SS.

Original languageEnglish
Pages (from-to)298-307
Number of pages10
JournalInternational Journal of Oral and Maxillofacial Surgery
Volume25
Issue number4
DOIs
Publication statusPublished - Jan 1 1996

Fingerprint

Graft vs Host Disease
HLA-DR Antigens
Epithelial Cells
Xerophthalmia
Lymphocytes
Xerostomia
Vascular Cell Adhesion Molecule-1
Lymphocyte Subsets
Cell Adhesion Molecules
Lip
Salivary Glands
B-Lymphocytes
Endothelial Cells
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

A comparison of glandular involvement between chronic graft-versus-host disease and Sjögren's syndrome. / Hiroki, Akiko; Nakamura, Seiji; Shinohara, Masanori; Gondo, Hisashi; Ohyama, Yukiko; Hayashi, Shin; Harada, Mine; Niho, Yoshiyuki; Oka, Masuichiro.

In: International Journal of Oral and Maxillofacial Surgery, Vol. 25, No. 4, 01.01.1996, p. 298-307.

Research output: Contribution to journalArticle

Hiroki, Akiko ; Nakamura, Seiji ; Shinohara, Masanori ; Gondo, Hisashi ; Ohyama, Yukiko ; Hayashi, Shin ; Harada, Mine ; Niho, Yoshiyuki ; Oka, Masuichiro. / A comparison of glandular involvement between chronic graft-versus-host disease and Sjögren's syndrome. In: International Journal of Oral and Maxillofacial Surgery. 1996 ; Vol. 25, No. 4. pp. 298-307.
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