A comparison of the logistic regression and the cox proportional hazard models in retrospective studies on the prognosis of patients with castric cancer

Sunao Moriguchi, Yoshio Hayashi, Yoshiaki Nose, Yoshihiko Maehara, Daisuke Korenaga, Keizo Sugimachi

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Abstract

To define the independent prognostic factors reducing survival time for gastric cancer, we compared the logistic regression and the Cox proportional hazard models applied to patients who underwent curative gastrec‐tomy. All patients were evaluated after being followed for long fixed periods. Of 1,019, 269 (26.4%) died of tumor recurrence within a 5‐year period and 36 (3.5%) died over 5 years after the original surgery. With regard to survival time, multivariate analyses using the Cox proportional hazard model in a stepwise manner adjusted for the sex, age, and 10 other factors, suggested that size of tumor (P<0.01, relative risk [rr] = 1.0962), degree of gastric wall invasion (P < 0.01, rr < 1.3520), and status of lymph node metastasis (P < 0.01, rr = 1.6572) were the most independent prognostic factors. As well as, using the stepwise logistic regression model, size of tumor, (P < 0.01, odds ratio [or] = 1.115), degree of gastric wall invasion (P < 0.01, or = 1.428), and status of lymph node metastasis (P < 0.01, or = 2.182) were also the most independent risk factors for recurrence within 5 years after surgery. Although regression coefficients are not all the same, these three factors proved significant in both multivariate analyses. This equation for risk factors for prognosis is approached when searching for an appropriate method of retrospective studies using multivariate analyses. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalJournal of Surgical Oncology
Volume52
Issue number1
DOIs
Publication statusPublished - Jan 1 1993

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Proportional Hazards Models
Multivariate Analysis
Retrospective Studies
Logistic Models
Odds Ratio
Stomach
Lymph Nodes
Neoplasm Metastasis
Recurrence
Neoplasms
Survival
Gastrectomy
Stomach Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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A comparison of the logistic regression and the cox proportional hazard models in retrospective studies on the prognosis of patients with castric cancer. / Moriguchi, Sunao; Hayashi, Yoshio; Nose, Yoshiaki; Maehara, Yoshihiko; Korenaga, Daisuke; Sugimachi, Keizo.

In: Journal of Surgical Oncology, Vol. 52, No. 1, 01.01.1993, p. 9-13.

Research output: Contribution to journalArticle

Moriguchi, Sunao ; Hayashi, Yoshio ; Nose, Yoshiaki ; Maehara, Yoshihiko ; Korenaga, Daisuke ; Sugimachi, Keizo. / A comparison of the logistic regression and the cox proportional hazard models in retrospective studies on the prognosis of patients with castric cancer. In: Journal of Surgical Oncology. 1993 ; Vol. 52, No. 1. pp. 9-13.
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