A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q

Comparison with chromosome 21q

Yoichi Yamada, Tomoyo Shirakawa, Todd D. Taylor, Kohji Okamura, Hidenobu Soejima, Michiko Uchiyama, Tsuyoshi Iwasaka, Tsunehiro Mukai, Ken Ichiro Muramoto, Yoshiyuki Sakaki, Takashi Ito

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

It was generally believed that autosomal CpG islands (CGIs) escape methylation. However, our comprehensive analysis of allelic methylation status of 149 CGIs on human chromosome 21q revealed that a sizable fraction of them are methylated on both alleles even in normal blood cells. Here, we performed a similar analysis of 656 CGIs on chromosome 11q, which is gene-rich in contrast with 21q. The results indicate that 11q contains less methylated CGIs, especially those with tandem repeats and those in the coding or 3′-untranslated regions (UTRs), than 21q. Thus, methylation status of CGIs may substantially differ from one chromosome to another.

Original languageEnglish
Pages (from-to)300-306
Number of pages7
JournalDNA Sequence - Journal of DNA Sequencing and Mapping
Volume17
Issue number4
DOIs
Publication statusPublished - Aug 1 2006
Externally publishedYes

Fingerprint

CpG Islands
Methylation
Human Chromosomes
Chromosomes
Tandem Repeat Sequences
3' Untranslated Regions
Blood Cells
Blood
Genes
Alleles
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Endocrinology

Cite this

A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q : Comparison with chromosome 21q. / Yamada, Yoichi; Shirakawa, Tomoyo; Taylor, Todd D.; Okamura, Kohji; Soejima, Hidenobu; Uchiyama, Michiko; Iwasaka, Tsuyoshi; Mukai, Tsunehiro; Muramoto, Ken Ichiro; Sakaki, Yoshiyuki; Ito, Takashi.

In: DNA Sequence - Journal of DNA Sequencing and Mapping, Vol. 17, No. 4, 01.08.2006, p. 300-306.

Research output: Contribution to journalArticle

Yamada, Y, Shirakawa, T, Taylor, TD, Okamura, K, Soejima, H, Uchiyama, M, Iwasaka, T, Mukai, T, Muramoto, KI, Sakaki, Y & Ito, T 2006, 'A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q: Comparison with chromosome 21q', DNA Sequence - Journal of DNA Sequencing and Mapping, vol. 17, no. 4, pp. 300-306. https://doi.org/10.1080/10425170600886128
Yamada, Yoichi ; Shirakawa, Tomoyo ; Taylor, Todd D. ; Okamura, Kohji ; Soejima, Hidenobu ; Uchiyama, Michiko ; Iwasaka, Tsuyoshi ; Mukai, Tsunehiro ; Muramoto, Ken Ichiro ; Sakaki, Yoshiyuki ; Ito, Takashi. / A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q : Comparison with chromosome 21q. In: DNA Sequence - Journal of DNA Sequencing and Mapping. 2006 ; Vol. 17, No. 4. pp. 300-306.
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