A computerized framework for monitoring four-dimensional dose distributions during stereotactic body radiation therapy using a portal dose image-based 2D/3D registration approach

Takahiro Nakamoto, Hidetaka Arimura, Katsumasa Nakamura, Yoshiyuki Shioyama, Asumi Mizoguchi, Taka aki Hirose, Hiroshi Honda, Yoshiyuki Umezu, Yasuhiko Nakamura, Hideki Hirata

Research output: Contribution to journalArticle

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Abstract

A computerized framework for monitoring four-dimensional (4D) dose distributions during stereotactic body radiation therapy based on a portal dose image (PDI)-based 2D/3D registration approach has been proposed in this study. Using the PDI-based registration approach, simulated 4D "treatment" CT images were derived from the deformation of 3D planning CT images so that a 2D planning PDI could be similar to a 2D dynamic clinical PDI at a breathing phase. The planning PDI was calculated by applying a dose calculation algorithm (a pencil beam convolution algorithm) to the geometry of the planning CT image and a virtual water equivalent phantom. The dynamic clinical PDIs were estimated from electronic portal imaging device (EPID) dynamic images including breathing phase data obtained during a treatment. The parameters of the affine transformation matrix were optimized based on an objective function and a gamma pass rate using a Levenberg-Marquardt (LM) algorithm. The proposed framework was applied to the EPID dynamic images of ten lung cancer patients, which included 183 frames (mean: 18.3 per patient). The 4D dose distributions during the treatment time were successfully obtained by applying the dose calculation algorithm to the simulated 4D "treatment" CT images. The mean ± standard deviation (SD) of the percentage errors between the prescribed dose and the estimated dose at an isocenter for all cases was 3.25 ± 4.43%. The maximum error for the ten cases was 14.67% (prescribed dose: 1.50. Gy, estimated dose: 1.72. Gy), and the minimum error was 0.00%. The proposed framework could be feasible for monitoring the 4D dose distribution and dose errors within a patient's body during treatment.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalComputerized Medical Imaging and Graphics
Volume40
DOIs
Publication statusPublished - Jan 1 2015

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Radiotherapy
Dosimetry
Four-Dimensional Computed Tomography
Monitoring
Planning
Respiration
Therapeutics
Equipment and Supplies
Imaging techniques
Lung Neoplasms
Convolution
Water
Geometry

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Graphics and Computer-Aided Design

Cite this

A computerized framework for monitoring four-dimensional dose distributions during stereotactic body radiation therapy using a portal dose image-based 2D/3D registration approach. / Nakamoto, Takahiro; Arimura, Hidetaka; Nakamura, Katsumasa; Shioyama, Yoshiyuki; Mizoguchi, Asumi; Hirose, Taka aki; Honda, Hiroshi; Umezu, Yoshiyuki; Nakamura, Yasuhiko; Hirata, Hideki.

In: Computerized Medical Imaging and Graphics, Vol. 40, 01.01.2015, p. 1-12.

Research output: Contribution to journalArticle

Nakamoto, Takahiro ; Arimura, Hidetaka ; Nakamura, Katsumasa ; Shioyama, Yoshiyuki ; Mizoguchi, Asumi ; Hirose, Taka aki ; Honda, Hiroshi ; Umezu, Yoshiyuki ; Nakamura, Yasuhiko ; Hirata, Hideki. / A computerized framework for monitoring four-dimensional dose distributions during stereotactic body radiation therapy using a portal dose image-based 2D/3D registration approach. In: Computerized Medical Imaging and Graphics. 2015 ; Vol. 40. pp. 1-12.
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