A conservation law for virus infection kinetics in vitro

Yusuke Kakizoe, Satoru Morita, Shinji Nakaoka, Yasuhiro Takeuchi, Kei Sato, Tomoyuki Miura, Catherine A.A. Beauchemin, Shingo Iwami

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Conservation laws are among the most important properties of a physical system, but are not commonplace in biology. We derived a conservation law from the basic model for viral infections which consists in a small set of ordinary differential equations. We challenged the conservation law experimentally for the case of a virus infection in a cell culture. We found that the derived, conserved quantity remained almost constant throughout the infection period, implying that the derived conservation law holds in this biological system. We also suggest a potential use for the conservation law in evaluating the accuracy of experimental measurements.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalJournal of Theoretical Biology
Volume376
DOIs
Publication statusPublished - Jul 7 2015

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Fingerprint Dive into the research topics of 'A conservation law for virus infection kinetics in vitro'. Together they form a unique fingerprint.

  • Cite this

    Kakizoe, Y., Morita, S., Nakaoka, S., Takeuchi, Y., Sato, K., Miura, T., Beauchemin, C. A. A., & Iwami, S. (2015). A conservation law for virus infection kinetics in vitro. Journal of Theoretical Biology, 376, 39-47. https://doi.org/10.1016/j.jtbi.2015.03.034