A conservation law for virus infection kinetics in vitro

Yusuke Kakizoe, Satoru Morita, Shinji Nakaoka, Yasuhiro Takeuchi, Kei Sato, Tomoyuki Miura, Catherine A.A. Beauchemin, Shingo Iwami

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Conservation laws are among the most important properties of a physical system, but are not commonplace in biology. We derived a conservation law from the basic model for viral infections which consists in a small set of ordinary differential equations. We challenged the conservation law experimentally for the case of a virus infection in a cell culture. We found that the derived, conserved quantity remained almost constant throughout the infection period, implying that the derived conservation law holds in this biological system. We also suggest a potential use for the conservation law in evaluating the accuracy of experimental measurements.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalJournal of Theoretical Biology
Volume376
DOIs
Publication statusPublished - Jul 7 2015

Fingerprint

Virus Diseases
Viruses
Conservation Laws
Virus
Infection
Conservation
Kinetics
kinetics
viruses
infection
Cell Culture Techniques
physical properties
cell culture
Cell Culture
Conserved Quantity
Biological Sciences
Biological systems
Cell culture
Biological Systems
Ordinary differential equations

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Medicine(all)
  • Modelling and Simulation
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Kakizoe, Y., Morita, S., Nakaoka, S., Takeuchi, Y., Sato, K., Miura, T., ... Iwami, S. (2015). A conservation law for virus infection kinetics in vitro. Journal of Theoretical Biology, 376, 39-47. https://doi.org/10.1016/j.jtbi.2015.03.034

A conservation law for virus infection kinetics in vitro. / Kakizoe, Yusuke; Morita, Satoru; Nakaoka, Shinji; Takeuchi, Yasuhiro; Sato, Kei; Miura, Tomoyuki; Beauchemin, Catherine A.A.; Iwami, Shingo.

In: Journal of Theoretical Biology, Vol. 376, 07.07.2015, p. 39-47.

Research output: Contribution to journalArticle

Kakizoe, Y, Morita, S, Nakaoka, S, Takeuchi, Y, Sato, K, Miura, T, Beauchemin, CAA & Iwami, S 2015, 'A conservation law for virus infection kinetics in vitro', Journal of Theoretical Biology, vol. 376, pp. 39-47. https://doi.org/10.1016/j.jtbi.2015.03.034
Kakizoe Y, Morita S, Nakaoka S, Takeuchi Y, Sato K, Miura T et al. A conservation law for virus infection kinetics in vitro. Journal of Theoretical Biology. 2015 Jul 7;376:39-47. https://doi.org/10.1016/j.jtbi.2015.03.034
Kakizoe, Yusuke ; Morita, Satoru ; Nakaoka, Shinji ; Takeuchi, Yasuhiro ; Sato, Kei ; Miura, Tomoyuki ; Beauchemin, Catherine A.A. ; Iwami, Shingo. / A conservation law for virus infection kinetics in vitro. In: Journal of Theoretical Biology. 2015 ; Vol. 376. pp. 39-47.
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