A coplanar PCB induces a selenium binding protein as a major cytosolic protein in rat liver

Yuji Ishii, Megumu Hatsumura, Takumi Ishida, Noritaka Ariyoshi, Kazuta Oguri

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We obtained evidence that a toxic coplanar polychlorinated biphenyl (PCB) induces a counterpart,of murine 56 kDa selenium binding protein in rat liver cytosol. A 54 kDa protein in the liver cytosol was significantly induced by 3,3',4,4',5-pentachlorobiphenyl and proved to be a major cytosolic protein in the rat liver. The protein exhibited pi of 6.8 on two-dimensional gel electrophoresis. The amino acid sequence of peptide fragments from the protein digested in situ, was highly similar to a 56 kDa selenium binding protein and similar to an acetaminophen binding protein in mice.

Original languageEnglish
Pages (from-to)509-515
Number of pages7
JournalChemosphere
Volume32
Issue number3
DOIs
Publication statusPublished - Jan 1 1996

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Chemistry(all)

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