TY - JOUR
T1 - A decreased survival of proliferated cells in the hippocampus is associated with a decline in spatial memory in aged rats
AU - Wati, Henny
AU - Kudo, Koutaro
AU - Qiao, Chunxiang
AU - Kuroki, Toshihide
AU - Kanba, Shigenobu
N1 - Funding Information:
This study was supported by the Target Oriented Brain Science Promotion Program and a grant from the Japanese Ministry of Culture, Sports and Science (No. 16390321). This study was also supported by grants from the Japanese Ministry of Health and Labor.
PY - 2006/5/15
Y1 - 2006/5/15
N2 - In aged rats, although learning and memory impairment is prominent, both the number of granular cells and the degree of neuronal progenitor proliferation in the hippocampus are known to be preserved. We examined the association between the survival of newly generated neurons in the hippocampus and the learning ability in aged rats. By using BrdU, a cell proliferation marker to determine neurogenesis and contextual fear conditioning to determine learning ability, we found that in aged rats, along with memory impairment, the survival of both the proliferated cells at baseline and those enhanced by contextual fear conditioning decreased remarkably. These results suggest that the integration of newly generated neurons into hippocampal circuitry is decreased with aging, this phenomenon may, in part, explain the decline in learning and memory in aged rats.
AB - In aged rats, although learning and memory impairment is prominent, both the number of granular cells and the degree of neuronal progenitor proliferation in the hippocampus are known to be preserved. We examined the association between the survival of newly generated neurons in the hippocampus and the learning ability in aged rats. By using BrdU, a cell proliferation marker to determine neurogenesis and contextual fear conditioning to determine learning ability, we found that in aged rats, along with memory impairment, the survival of both the proliferated cells at baseline and those enhanced by contextual fear conditioning decreased remarkably. These results suggest that the integration of newly generated neurons into hippocampal circuitry is decreased with aging, this phenomenon may, in part, explain the decline in learning and memory in aged rats.
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U2 - 10.1016/j.neulet.2006.01.056
DO - 10.1016/j.neulet.2006.01.056
M3 - Article
C2 - 16513267
AN - SCOPUS:33646118726
VL - 399
SP - 171
EP - 174
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -