A delayed type hypersensitivity (DTH) skin reaction to hepatitis B surface antigen (HBsAg) and intradermal hepatitis B vaccination.

Seiho Nagafuchi, Seizaburo Kashiwagi, Jun Hayashi, Hitoshi Katsuta, Hideyuki Ikematsu, Mine Harada

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The significance of a delayed type hypersensitivity skin reaction to hepatitis B surface antigen (HBsAg) (HBs-DTH) in type B viral hepatitis (VHB) and in intradermal hepatitis B (HB) vaccination is reviewed. HBs-DTH could be developed by the intradermal injection of HB vaccine in anti-HBs positive people and also in persons immunized with HB vaccine. Thus, HBs-DTH could serve as a useful marker for the acquisition of an active Th1 type immunoreactivity to HBsAg. HBs-DTH was absent in patients with chronic VHB. In contrast, HBs-DTH developed early in the convalescent phase of the acute VHB, whereas the production of anti-HBs was significantly delayed, thus suggesting that HBs-DTH may be involved in the recovery mechanisms of acute VHB. Intradermal HB vaccination is useful not only in lowering the cost, but also in the rapid development of anti-HBs, reversing non-responsiveness, improving postexposure prophylaxis and in immunizing immunosuppressed people. A similar vaccination strategy should prove to be useful in prevention and control of not only other infectious diseases but also malignant neoplasms.

Original languageEnglish
Pages (from-to)305-313
Number of pages9
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume95
Issue number12
Publication statusPublished - Jan 1 2004

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Delayed Hypersensitivity
Hepatitis B Surface Antigens
Hepatitis B
Vaccination
Skin
Hepatitis B Vaccines
Intradermal Injections
Communicable Diseases
Costs and Cost Analysis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

A delayed type hypersensitivity (DTH) skin reaction to hepatitis B surface antigen (HBsAg) and intradermal hepatitis B vaccination. / Nagafuchi, Seiho; Kashiwagi, Seizaburo; Hayashi, Jun; Katsuta, Hitoshi; Ikematsu, Hideyuki; Harada, Mine.

In: Fukuoka igaku zasshi = Hukuoka acta medica, Vol. 95, No. 12, 01.01.2004, p. 305-313.

Research output: Contribution to journalReview article

Nagafuchi, Seiho ; Kashiwagi, Seizaburo ; Hayashi, Jun ; Katsuta, Hitoshi ; Ikematsu, Hideyuki ; Harada, Mine. / A delayed type hypersensitivity (DTH) skin reaction to hepatitis B surface antigen (HBsAg) and intradermal hepatitis B vaccination. In: Fukuoka igaku zasshi = Hukuoka acta medica. 2004 ; Vol. 95, No. 12. pp. 305-313.
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AU - Katsuta, Hitoshi

AU - Ikematsu, Hideyuki

AU - Harada, Mine

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