A design strategy of a bioreactor for platelet production using fluid force

Hiroki Kumon, Shinya Sakuma, Sou Nakamura, Koji Eto, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we showed that platelets were produced from megakaryocytes using a bioreactor with a slope shaped 3D microchannel by applying fluid force. In previous studies, slit structures have been utilized to produce platelets in a microfluidic chip. However, it is difficult to trap megakaryocytes of various size by using the pre-patterned slit structures. Therefore, we present a bioreactor which can trap various size of megakaryocytes. In this study, we constructed a bioreactor with a slope shaped 3D microchannel, and succeed in on-chip platelet production.

Original languageEnglish
Title of host publicationMHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1-2
Number of pages2
ISBN (Electronic)9781538633144
DOIs
Publication statusPublished - Feb 28 2018
Externally publishedYes
Event28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017 - Nagoya, Japan
Duration: Dec 3 2017Dec 6 2017

Publication series

NameMHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
Volume2018-January

Other

Other28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017
CountryJapan
CityNagoya
Period12/3/1712/6/17

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Mechanical Engineering

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