A design strategy of a bioreactor for platelet production using fluid force

Hiroki Kumon; Shinya Sakuma; Sou Nakamura; Koji Eto; Fumihito Arai

doi:10.1109/MHS.2017.8305248

A design strategy of a bioreactor for platelet production using fluid force

Hiroki Kumon, Shinya Sakuma, Sou Nakamura, Koji Eto, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this study, we showed that platelets were produced from megakaryocytes using a bioreactor with a slope shaped 3D microchannel by applying fluid force. In previous studies, slit structures have been utilized to produce platelets in a microfluidic chip. However, it is difficult to trap megakaryocytes of various size by using the pre-patterned slit structures. Therefore, we present a bioreactor which can trap various size of megakaryocytes. In this study, we constructed a bioreactor with a slope shaped 3D microchannel, and succeed in on-chip platelet production.

Original language	English
Title of host publication	MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1-2
Number of pages	2
ISBN (Electronic)	9781538633144
DOIs	https://doi.org/10.1109/MHS.2017.8305248
Publication status	Published - Feb 28 2018
Externally published	Yes
Event	28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017 - Nagoya, Japan Duration: Dec 3 2017 → Dec 6 2017

Publication series

Name	MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
Volume	2018-January

Other

Other	28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017
Country/Territory	Japan
City	Nagoya
Period	12/3/17 → 12/6/17

All Science Journal Classification (ASJC) codes

Biotechnology
Biomedical Engineering
Electrical and Electronic Engineering
Mechanical Engineering

Access to Document

10.1109/MHS.2017.8305248

Cite this

Kumon, H., Sakuma, S., Nakamura, S., Eto, K., & Arai, F. (2018). A design strategy of a bioreactor for platelet production using fluid force. In MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science (pp. 1-2). (MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science; Vol. 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MHS.2017.8305248

A design strategy of a bioreactor for platelet production using fluid force. / Kumon, Hiroki; Sakuma, Shinya; Nakamura, Sou et al.

MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science. Institute of Electrical and Electronics Engineers Inc., 2018. p. 1-2 (MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science; Vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kumon, H, Sakuma, S, Nakamura, S, Eto, K & Arai, F 2018, A design strategy of a bioreactor for platelet production using fluid force. in MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science. MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science, vol. 2018-January, Institute of Electrical and Electronics Engineers Inc., pp. 1-2, 28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017, Nagoya, Japan, 12/3/17. https://doi.org/10.1109/MHS.2017.8305248

Kumon H, Sakuma S, Nakamura S, Eto K, Arai F. A design strategy of a bioreactor for platelet production using fluid force. In MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science. Institute of Electrical and Electronics Engineers Inc. 2018. p. 1-2. (MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science). doi: 10.1109/MHS.2017.8305248

Kumon, Hiroki ; Sakuma, Shinya ; Nakamura, Sou et al. / A design strategy of a bioreactor for platelet production using fluid force. MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 1-2 (MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science).

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abstract = "In this study, we showed that platelets were produced from megakaryocytes using a bioreactor with a slope shaped 3D microchannel by applying fluid force. In previous studies, slit structures have been utilized to produce platelets in a microfluidic chip. However, it is difficult to trap megakaryocytes of various size by using the pre-patterned slit structures. Therefore, we present a bioreactor which can trap various size of megakaryocytes. In this study, we constructed a bioreactor with a slope shaped 3D microchannel, and succeed in on-chip platelet production.",

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N2 - In this study, we showed that platelets were produced from megakaryocytes using a bioreactor with a slope shaped 3D microchannel by applying fluid force. In previous studies, slit structures have been utilized to produce platelets in a microfluidic chip. However, it is difficult to trap megakaryocytes of various size by using the pre-patterned slit structures. Therefore, we present a bioreactor which can trap various size of megakaryocytes. In this study, we constructed a bioreactor with a slope shaped 3D microchannel, and succeed in on-chip platelet production.

AB - In this study, we showed that platelets were produced from megakaryocytes using a bioreactor with a slope shaped 3D microchannel by applying fluid force. In previous studies, slit structures have been utilized to produce platelets in a microfluidic chip. However, it is difficult to trap megakaryocytes of various size by using the pre-patterned slit structures. Therefore, we present a bioreactor which can trap various size of megakaryocytes. In this study, we constructed a bioreactor with a slope shaped 3D microchannel, and succeed in on-chip platelet production.

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A design strategy of a bioreactor for platelet production using fluid force

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