A dual alkylated peptide-ligand enhances affinity to human serum albumin

Elnaz Nakhaei, Ko Takehara, Hikari Sato, Khadijah Zai, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Therapeutic peptides and diagnostic agents with their molecular size below the renal clearance threshold suffer from short blood circulation time. Here, we report a novel design of peptide-based ligand with a strong binding affinity to human serum albumin (HSA), which can be used as a tag to extend the blood circulation of small-size molecules. We designed ligands with dual alkyl groups connected with a negatively charged spacer. The ligands showed both higher binding affinity to HSA and a higher retention in mice blood than that of a single alkylated peptide.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
Journalanalytical sciences
Volume34
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

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Serum Albumin
Hemodynamics
Ligands
Peptides
Blood
Molecules

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

Cite this

A dual alkylated peptide-ligand enhances affinity to human serum albumin. / Nakhaei, Elnaz; Takehara, Ko; Sato, Hikari; Zai, Khadijah; Kishimura, Akihiro; Mori, Takeshi; Katayama, Yoshiki.

In: analytical sciences, Vol. 34, No. 4, 01.01.2018, p. 501-504.

Research output: Contribution to journalArticle

Nakhaei, Elnaz ; Takehara, Ko ; Sato, Hikari ; Zai, Khadijah ; Kishimura, Akihiro ; Mori, Takeshi ; Katayama, Yoshiki. / A dual alkylated peptide-ligand enhances affinity to human serum albumin. In: analytical sciences. 2018 ; Vol. 34, No. 4. pp. 501-504.
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