A dual alkylated peptide-ligand enhances affinity to human serum albumin

Elnaz Nakhaei, Ko Takehara, Hikari Sato, Khadijah Zai, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Therapeutic peptides and diagnostic agents with their molecular size below the renal clearance threshold suffer from short blood circulation time. Here, we report a novel design of peptide-based ligand with a strong binding affinity to human serum albumin (HSA), which can be used as a tag to extend the blood circulation of small-size molecules. We designed ligands with dual alkyl groups connected with a negatively charged spacer. The ligands showed both higher binding affinity to HSA and a higher retention in mice blood than that of a single alkylated peptide.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
Journalanalytical sciences
Volume34
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

Fingerprint Dive into the research topics of 'A dual alkylated peptide-ligand enhances affinity to human serum albumin'. Together they form a unique fingerprint.

Cite this