Abstract
Therapeutic peptides and diagnostic agents with their molecular size below the renal clearance threshold suffer from short blood circulation time. Here, we report a novel design of peptide-based ligand with a strong binding affinity to human serum albumin (HSA), which can be used as a tag to extend the blood circulation of small-size molecules. We designed ligands with dual alkyl groups connected with a negatively charged spacer. The ligands showed both higher binding affinity to HSA and a higher retention in mice blood than that of a single alkylated peptide.
Original language | English |
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Pages (from-to) | 501-504 |
Number of pages | 4 |
Journal | analytical sciences |
Volume | 34 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jan 1 2018 |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry