A Facile Surface Functionalization Method for Polymers Using a Nonsolvent

Toyoaki Hirata; Hidenobu Taneda; Kazuya Nishio; Manabu Inutsuka; Norifumi L. Yamada; Fumiya Nemoto; Yasuhisa Minagawa; Hisao Matsuno; Keiji Tanaka

doi:10.1021/acsabm.0c00028

A Facile Surface Functionalization Method for Polymers Using a Nonsolvent

Toyoaki Hirata, Hidenobu Taneda, Kazuya Nishio, Manabu Inutsuka, Norifumi L. Yamada, Fumiya Nemoto, Yasuhisa Minagawa, Hisao Matsuno, Keiji Tanaka

Applied Fine Chemistry

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1 Citation (Scopus)

Abstract

Surface treatment of polymeric solids without impairing their bulk properties is a crucial functionalization strategy for the promotion of their wider application. We here propose a facile method using a nonsolvent which can subtly alter or swell the polymer surface to be modified. A thin film of poly(methyl methacrylate) (PMMA) was immersed in a methanol solution of poly(2-methoxyethyl acrylate) (PMEA). Electron spectroscopy for chemical analysis and neutron reflectometry revealed that a PMEA layer formed on the PMMA film with a diffused interface. The PMEA layer was very swollen in water and exhibited the ability to suppress serum protein adsorption and platelet adhesion on it. The functionalization technique using a nonsolvent was also applicable to the surface of other polymeric solids such as polyurethane.

Original language	English
Pages (from-to)	2170-2176
Number of pages	7
Journal	ACS Applied Bio Materials
Volume	3
Issue number	4
DOIs	https://doi.org/10.1021/acsabm.0c00028
Publication status	Published - Apr 20 2020

All Science Journal Classification (ASJC) codes

Biomaterials
Chemistry(all)
Biomedical Engineering
Biochemistry, medical

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A Facile Surface Functionalization Method for Polymers Using a Nonsolvent. / Hirata, Toyoaki; Taneda, Hidenobu; Nishio, Kazuya; Inutsuka, Manabu; Yamada, Norifumi L.; Nemoto, Fumiya; Minagawa, Yasuhisa; Matsuno, Hisao ; Tanaka, Keiji.

In: ACS Applied Bio Materials, Vol. 3, No. 4, 20.04.2020, p. 2170-2176.

Research output: Contribution to journal › Article › peer-review

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title = "A Facile Surface Functionalization Method for Polymers Using a Nonsolvent",

abstract = "Surface treatment of polymeric solids without impairing their bulk properties is a crucial functionalization strategy for the promotion of their wider application. We here propose a facile method using a nonsolvent which can subtly alter or swell the polymer surface to be modified. A thin film of poly(methyl methacrylate) (PMMA) was immersed in a methanol solution of poly(2-methoxyethyl acrylate) (PMEA). Electron spectroscopy for chemical analysis and neutron reflectometry revealed that a PMEA layer formed on the PMMA film with a diffused interface. The PMEA layer was very swollen in water and exhibited the ability to suppress serum protein adsorption and platelet adhesion on it. The functionalization technique using a nonsolvent was also applicable to the surface of other polymeric solids such as polyurethane.",

author = "Toyoaki Hirata and Hidenobu Taneda and Kazuya Nishio and Manabu Inutsuka and Yamada, {Norifumi L.} and Fumiya Nemoto and Yasuhisa Minagawa and Hisao Matsuno and Keiji Tanaka",

note = "Funding Information: We thank for the support from the JST-Mirai Program (JPMJMI18A2) (K.T.) and from JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (JP18H02037) (H.M.). The NR experiment was approved by the Neutron Scattering Program Advisory Committee of IMSS, KEK with Proposal Nos. 2016A0069, 2016B100, 2017A0197, 2017B0302, 2018A0269, 2018B0293, and 2017L2501. Publisher Copyright: Copyright {\textcopyright} 2020 American Chemical Society. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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AU - Hirata, Toyoaki

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AU - Nemoto, Fumiya

AU - Minagawa, Yasuhisa

AU - Matsuno, Hisao

AU - Tanaka, Keiji

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PY - 2020/4/20

Y1 - 2020/4/20

N2 - Surface treatment of polymeric solids without impairing their bulk properties is a crucial functionalization strategy for the promotion of their wider application. We here propose a facile method using a nonsolvent which can subtly alter or swell the polymer surface to be modified. A thin film of poly(methyl methacrylate) (PMMA) was immersed in a methanol solution of poly(2-methoxyethyl acrylate) (PMEA). Electron spectroscopy for chemical analysis and neutron reflectometry revealed that a PMEA layer formed on the PMMA film with a diffused interface. The PMEA layer was very swollen in water and exhibited the ability to suppress serum protein adsorption and platelet adhesion on it. The functionalization technique using a nonsolvent was also applicable to the surface of other polymeric solids such as polyurethane.

AB - Surface treatment of polymeric solids without impairing their bulk properties is a crucial functionalization strategy for the promotion of their wider application. We here propose a facile method using a nonsolvent which can subtly alter or swell the polymer surface to be modified. A thin film of poly(methyl methacrylate) (PMMA) was immersed in a methanol solution of poly(2-methoxyethyl acrylate) (PMEA). Electron spectroscopy for chemical analysis and neutron reflectometry revealed that a PMEA layer formed on the PMMA film with a diffused interface. The PMEA layer was very swollen in water and exhibited the ability to suppress serum protein adsorption and platelet adhesion on it. The functionalization technique using a nonsolvent was also applicable to the surface of other polymeric solids such as polyurethane.

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A Facile Surface Functionalization Method for Polymers Using a Nonsolvent

Abstract

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