A facile synthesis of (2R/S,5R)-1-tert-butyl 2-methyl 5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidine-1,2-dicarboxylate

Yoko Yasuno, Yuya Yoshida, Akito Nishimura, Yasufumi Ohfune, Tetsuro Shinada

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A facile synthesis of (2R/S,5R)-1-tert-butyl 2-methyl 5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidine-1,2-dicarboxylate (12) was efficiently accomplished in 5 steps from aminal 17 via the mild hydrolysis of nitrile 23.

Original languageEnglish
Pages (from-to)2377-2385
Number of pages9
JournalHeterocycles
Volume91
Issue number12
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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