A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission

Koushik Dhara; Yuichiro Hori; Reisuke Baba; Kazuya Kikuchi

doi:10.1039/c2cc36591j

A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission

Koushik Dhara, Yuichiro Hori, Reisuke Baba, Kazuya Kikuchi

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

A tetraphenylethylene-derivative fluorescent probe for the one-step detection of histone deacetylases (HDAC) was developed. The deacetylation of the probe triggers electrostatic interaction between the molecules and automatically leads to fluorescence enhancement based on aggregation-induced emission (AIE).

Original language	English
Pages (from-to)	11534-11536
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	94
DOIs	https://doi.org/10.1039/c2cc36591j
Publication status	Published - Oct 31 2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc36591j

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title = "A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission",

abstract = "A tetraphenylethylene-derivative fluorescent probe for the one-step detection of histone deacetylases (HDAC) was developed. The deacetylation of the probe triggers electrostatic interaction between the molecules and automatically leads to fluorescence enhancement based on aggregation-induced emission (AIE).",

author = "Koushik Dhara and Yuichiro Hori and Reisuke Baba and Kazuya Kikuchi",

year = "2012",

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doi = "10.1039/c2cc36591j",

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AU - Dhara, Koushik

AU - Hori, Yuichiro

AU - Baba, Reisuke

AU - Kikuchi, Kazuya

PY - 2012/10/31

Y1 - 2012/10/31

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AB - A tetraphenylethylene-derivative fluorescent probe for the one-step detection of histone deacetylases (HDAC) was developed. The deacetylation of the probe triggers electrostatic interaction between the molecules and automatically leads to fluorescence enhancement based on aggregation-induced emission (AIE).

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JO - Chemical Communications

JF - Chemical Communications

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A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission

Abstract

All Science Journal Classification (ASJC) codes

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