This paper describes the enantioselective synthesis of key fragments (12, 18, 24, and 35) for the synthesis of aplysiatoxin (1a), a potent cancer promoter, and their convergent assembly to Kishi's aldehyde (2). Since 2 has already been transformed into 1a in a short step, its synthesis constitutes a formal total synthesis of 1a. Synthesis of fragments of aplysiatoxin (1a) and their convergent assembly to the key intermediate, Kishi's aldehyde (2), for the synthesis of 1a are described.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry