TY - JOUR
T1 - A functional MRI comparison of patients with obsessive-compulsive disorder and normal controls during a Chinese character Stroop task
AU - Nakao, Tomohiro
AU - Nakagawa, Akiko
AU - Yoshiura, Takashi
AU - Nakatani, Eriko
AU - Nabeyama, Maiko
AU - Yoshizato, Chika
AU - Kudoh, Akiko
AU - Tada, Kyoko
AU - Yoshioka, Kazuko
AU - Kawamoto, Midori
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Scientific Research (C) (14570931) from the Ministry of Education, Culture, Sports, Science and Technology and a Research Grant (14A-1) for Nervous and Mental Disorders from the Ministry of Health, Labour and Welfare. We thank T. Tashiro, M.D., Ph.D., whose effort in launching this research was invaluable. We also thank S. Kanba, M.D., Ph.D., and T. Kuroki, M.D., Ph.D., for their academic support of this research.
PY - 2005/7/30
Y1 - 2005/7/30
N2 - Recent functional neuroimaging and neuropsychological studies have suggested that abnormal activity in the anterior cingulate cortex (ACC) might cause an action-monitoring dysfunction in obsessive-compulsive disorder (OCD). To identify the relationship between brain dysfunction and cognitive dysfunction, we examined regional brain changes in OCD with functional magnetic resonance imaging (fMRI) during the performance of a cognitive task. Participants comprised 24 patients with OCD and 14 normal controls. First, we compared the cognitive function in the two groups as assessed by several neuropsychological tests. Then we used fMRI to explore brain correlates of their performance during the Chinese character version of the Stroop test, a task that is strongly related to action-monitoring function. The two groups did not differ on the neuropsychological tests. Both groups also showed similar activation pattern on fMRI. The patients, however, showed weaker activation than the normal controls in the ACC and the right caudate nucleus.
AB - Recent functional neuroimaging and neuropsychological studies have suggested that abnormal activity in the anterior cingulate cortex (ACC) might cause an action-monitoring dysfunction in obsessive-compulsive disorder (OCD). To identify the relationship between brain dysfunction and cognitive dysfunction, we examined regional brain changes in OCD with functional magnetic resonance imaging (fMRI) during the performance of a cognitive task. Participants comprised 24 patients with OCD and 14 normal controls. First, we compared the cognitive function in the two groups as assessed by several neuropsychological tests. Then we used fMRI to explore brain correlates of their performance during the Chinese character version of the Stroop test, a task that is strongly related to action-monitoring function. The two groups did not differ on the neuropsychological tests. Both groups also showed similar activation pattern on fMRI. The patients, however, showed weaker activation than the normal controls in the ACC and the right caudate nucleus.
UR - http://www.scopus.com/inward/record.url?scp=21344450910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21344450910&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2004.12.004
DO - 10.1016/j.pscychresns.2004.12.004
M3 - Article
C2 - 15970434
AN - SCOPUS:21344450910
SN - 0925-4927
VL - 139
SP - 101
EP - 114
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 2
ER -
