A functional [NiFe]hydrogenase mimic that catalyzes electron and hydride transfer from H2

Seiji Ogo, Koji Ichikawa, Takahiro Kishima, Takahiro Matsumoto, Hidetaka Nakai, Katsuhiro Kusaka, Takashi Ohhara

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Chemists have long sought to mimic enzymatic hydrogen activation with structurally simpler compounds. Here, we report a functional [NiFe]-based model of [NiFe]hydrogenase enzymes. This complex heterolytically activates hydrogen to form a hydride complex that is capable of reducing substrates by either hydride ion or electron transfer. Structural investigations were performed by a range of techniques, including x-ray diffraction and neutron scattering, resulting in crystal structures and the finding that the hydrido ligand is predominantly associated with the Fe center. The ligand's hydridic character is manifested in its reactivity with strong acid to liberate H2.

Original languageEnglish
Pages (from-to)682-684
Number of pages3
JournalScience
Volume339
Issue number6120
DOIs
Publication statusPublished - Feb 8 2013

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Hydrogen
Neutron Diffraction
Electrons
Ligands
X-Rays
Ions
Acids
Enzymes
nickel-iron hydrogenase

All Science Journal Classification (ASJC) codes

  • General

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A functional [NiFe]hydrogenase mimic that catalyzes electron and hydride transfer from H2 . / Ogo, Seiji; Ichikawa, Koji; Kishima, Takahiro; Matsumoto, Takahiro; Nakai, Hidetaka; Kusaka, Katsuhiro; Ohhara, Takashi.

In: Science, Vol. 339, No. 6120, 08.02.2013, p. 682-684.

Research output: Contribution to journalArticle

Ogo, S, Ichikawa, K, Kishima, T, Matsumoto, T, Nakai, H, Kusaka, K & Ohhara, T 2013, 'A functional [NiFe]hydrogenase mimic that catalyzes electron and hydride transfer from H2 ', Science, vol. 339, no. 6120, pp. 682-684. https://doi.org/10.1126/science.1231345
Ogo, Seiji ; Ichikawa, Koji ; Kishima, Takahiro ; Matsumoto, Takahiro ; Nakai, Hidetaka ; Kusaka, Katsuhiro ; Ohhara, Takashi. / A functional [NiFe]hydrogenase mimic that catalyzes electron and hydride transfer from H2 . In: Science. 2013 ; Vol. 339, No. 6120. pp. 682-684.
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