A fundamental study for quantitative measurement of ultrasound contrast concentration by low mechanical index contrast ultrasonography

Satoshi Yamada, Kaoru Komuro, Mariko Taniguchi, Ayumi Uranishi, Hiroshi Komatsu, Toshihiko Asanuma, Fuminobu Ishikura, Hisao Onozuka, Taisei Mikami, Hiroyuki Tsutsui, Shintaro Beppu

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Abstract

Purpose. In high mechanical index (MI) contrast ultrasonography it has been shown that the power of contrast signal intensity (CI) has a strong linear correlation with the concentration of the ultrasound contrast agent under conditions of constant applied acoustic pressure. However, it is unclear whether the linearity is preserved in low-MI contrast ultrasonography. Thus, we investigated the relationship between ultrasound contrast concentration and CI in vitro. Methods. Solutions of the ultrasound contrast agents Definity and Imagent were prepared at concentrations of 0.5, 2, 8, 32, and 128 μl/l. Placing a jelly block between the transducer and the solution, the solutions were transmitted using pulse subtraction imaging with an MI of 0.05, 0.1, and 0.5. CI was measured in dB in a region of interest 3 mm in height placed just below the border between the jelly and the solution. Data were plotted using double logarithm scales, where the concentration was expressed in dB as 10 × log (concentration). Results. CI in dB had a strong linear correlation with concentration in dB for both agents with any MI. Best fitted slopes were close to 1, indicating that the power of CI is proportional to the concentration. Conclusions. In low-MI contrast ultrasonography, the power of CI is proportional to contrast concentration, and CI in dB is logarithmic to the concentration. Thus, the microbubble concentration can be quantitatively measured even in low-MI contrast ultrasonography.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalJournal of Medical Ultrasonics
Volume33
Issue number2
DOIs
Publication statusPublished - Jun 1 2006
Externally publishedYes

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Ultrasonography
Contrast Media
Microbubbles
Transducers
Acoustics
Pressure

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

A fundamental study for quantitative measurement of ultrasound contrast concentration by low mechanical index contrast ultrasonography. / Yamada, Satoshi; Komuro, Kaoru; Taniguchi, Mariko; Uranishi, Ayumi; Komatsu, Hiroshi; Asanuma, Toshihiko; Ishikura, Fuminobu; Onozuka, Hisao; Mikami, Taisei; Tsutsui, Hiroyuki; Beppu, Shintaro.

In: Journal of Medical Ultrasonics, Vol. 33, No. 2, 01.06.2006, p. 77-83.

Research output: Contribution to journalArticle

Yamada, S, Komuro, K, Taniguchi, M, Uranishi, A, Komatsu, H, Asanuma, T, Ishikura, F, Onozuka, H, Mikami, T, Tsutsui, H & Beppu, S 2006, 'A fundamental study for quantitative measurement of ultrasound contrast concentration by low mechanical index contrast ultrasonography', Journal of Medical Ultrasonics, vol. 33, no. 2, pp. 77-83. https://doi.org/10.1007/s10396-006-0089-8
Yamada, Satoshi ; Komuro, Kaoru ; Taniguchi, Mariko ; Uranishi, Ayumi ; Komatsu, Hiroshi ; Asanuma, Toshihiko ; Ishikura, Fuminobu ; Onozuka, Hisao ; Mikami, Taisei ; Tsutsui, Hiroyuki ; Beppu, Shintaro. / A fundamental study for quantitative measurement of ultrasound contrast concentration by low mechanical index contrast ultrasonography. In: Journal of Medical Ultrasonics. 2006 ; Vol. 33, No. 2. pp. 77-83.
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AU - Asanuma, Toshihiko

AU - Ishikura, Fuminobu

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